DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, H | ko |
dc.contributor.author | Lee, SJ | ko |
dc.contributor.author | Suzuki, E | ko |
dc.contributor.author | Dugan, KD | ko |
dc.contributor.author | Stoddard, A | ko |
dc.contributor.author | Li, HS | ko |
dc.contributor.author | Chodosh, LA | ko |
dc.contributor.author | Montell, C | ko |
dc.date.accessioned | 2019-03-19T01:37:27Z | - |
dc.date.available | 2019-03-19T01:37:27Z | - |
dc.date.created | 2019-03-06 | - |
dc.date.issued | 2004-02 | - |
dc.identifier.citation | EMBO JOURNAL, v.23, no.4, pp.811 - 822 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251734 | - |
dc.description.abstract | The Drosophila visual system has provided a model to study phototransduction and retinal degeneration. To identify new candidate proteins that contribute to these processes, we conducted a genome-wide screen for genes expressed predominately in the eye, using DNA microarrays. This screen appeared to be comprehensive as it led to the identification of all 22 eye-enriched genes previously shown to function in phototransduction or implicated in retinal degeneration. In addition, we identified 93 eye-enriched genes whose roles have not been previously defined. One of the eye-enriched genes encoded a member of a large family of transmembrane proteins, referred to as tetraspanins. We created a null mutation in the eye-enriched tetraspanin, Sunglasses (Sun), which resulted in light-induced retinal degeneration. We found that the Sun protein was distributed primarily in lysosomes, and functioned in a long-known but poorly understood phenomenon of light-induced degradation of rhodopsin. We propose that lysosomal tetraspanins in mammalian cells may also function in the downregulation of rhodopsin and other G-protein-coupled receptors, in response to intense or prolonged agonist stimulation. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen | - |
dc.type | Article | - |
dc.identifier.wosid | 000220694100014 | - |
dc.identifier.scopusid | 2-s2.0-1842614338 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 811 | - |
dc.citation.endingpage | 822 | - |
dc.citation.publicationname | EMBO JOURNAL | - |
dc.identifier.doi | 10.1038/sj.emboj.7600112 | - |
dc.contributor.localauthor | Lee, SJ | - |
dc.contributor.nonIdAuthor | Xu, H | - |
dc.contributor.nonIdAuthor | Suzuki, E | - |
dc.contributor.nonIdAuthor | Dugan, KD | - |
dc.contributor.nonIdAuthor | Stoddard, A | - |
dc.contributor.nonIdAuthor | Li, HS | - |
dc.contributor.nonIdAuthor | Chodosh, LA | - |
dc.contributor.nonIdAuthor | Montell, C | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | microarray | - |
dc.subject.keywordAuthor | phototransduction | - |
dc.subject.keywordAuthor | retinal degeneration | - |
dc.subject.keywordAuthor | rhodopsin | - |
dc.subject.keywordAuthor | tetraspanin | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PHOTORECEPTOR CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ARRESTIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | CDNA | - |
dc.subject.keywordPlus | INAD | - |
dc.subject.keywordPlus | TRP | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
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