DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Jae | ko |
dc.contributor.author | Murphy, Coleen T. | ko |
dc.contributor.author | Kenyon, Cynthia | ko |
dc.date.accessioned | 2019-03-19T01:37:15Z | - |
dc.date.available | 2019-03-19T01:37:15Z | - |
dc.date.created | 2019-03-06 | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | CELL METABOLISM, v.10, no.5, pp.379 - 391 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251727 | - |
dc.description.abstract | Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the life span-shortening effect of glucose and that aqp-1 may act cell nonautonomously as a feedback regulator in the insulin/IGF-1-signaling pathway. Insulin downregulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression | - |
dc.type | Article | - |
dc.identifier.wosid | 000271498700007 | - |
dc.identifier.scopusid | 2-s2.0-70350365110 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 379 | - |
dc.citation.endingpage | 391 | - |
dc.citation.publicationname | CELL METABOLISM | - |
dc.identifier.doi | 10.1016/j.cmet.2009.10.003 | - |
dc.contributor.localauthor | Lee, Seung-Jae | - |
dc.contributor.nonIdAuthor | Murphy, Coleen T. | - |
dc.contributor.nonIdAuthor | Kenyon, Cynthia | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HEAT-SHOCK FACTOR | - |
dc.subject.keywordPlus | NEMATODE CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | GLYCEROL CHANNEL | - |
dc.subject.keywordPlus | HUMAN LONGEVITY | - |
dc.subject.keywordPlus | STRESS RESISTANCE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PROTEIN DAF-16 | - |
dc.subject.keywordPlus | GLYCEMIC INDEX | - |
dc.subject.keywordPlus | INSULIN | - |
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