Microtubes with Rectangular Cross-Section by Self-Assembly of a Short beta-Peptide Foldamer

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In nature, complex and well-defined structures are constructed by the self-assembly of biomolecules. It has been shown that beta-peptide foldamers can mimic natural peptides and self-assemble into three-dimensional molecular architectures thanks to their rigid and predictable helical conformation in solution. Using shorter foldamers, which can be prepared more easily than longer ones, to form such architectures is highly desirable, but shorter foldamers have been overlooked due to the seemingly inferior number of intramolecular hydrogen bonds to stabilize a folded state in solution. Here we report that a beta-peptide tetramer, although it lacks full helical propensity in solution, does self-assemble to form well-defined microtubes with rectangular cross-section by evaporation-induced self-assembly.
Publisher
AMER CHEMICAL SOC
Issue Date
2012
Language
English
Article Type
Article
Keywords

LYOTROPIC LIQUID-CRYSTALS; SECONDARY STRUCTURE; ORGANIC MICROTUBES; NANOTUBES; NANOFIBERS; OLIGOMERS; PHASE

Citation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.134, no.51, pp.20573 - 20576

ISSN
0002-7863
DOI
10.1021/ja3088482
URI
http://hdl.handle.net/10203/251051
Appears in Collection
CH-Journal Papers(저널논문)
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