DC Field | Value | Language |
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dc.contributor.author | Yang, Hee-Man | - |
dc.contributor.author | Park, Chan Woo | - |
dc.contributor.author | Woo, Min-Ah | - |
dc.contributor.author | Kim, Moon Il | - |
dc.contributor.author | Jo, Yeong Min | - |
dc.contributor.author | Park, Hyun Gyu | - |
dc.contributor.author | Kim, Jong-Duk | - |
dc.date.accessioned | 2011-08-30T04:27:39Z | - |
dc.date.available | 2011-08-30T04:27:39Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | Biomacromolecules, Vol.11, pp.2866-2872 | en |
dc.identifier.uri | http://hdl.handle.net/10203/25020 | - |
dc.description.abstract | Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). Water-soluble iron oxide nanoparticles were synthesized by coating iron oxide nanoparticles with a hydrophilic, biocompatible, biodegradable poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide) graft copolymer for negative contrast enhancement on T2 weighted MRI. HER2/neu antibodies were conjugated on the surface of poly(amino acid) coated iron oxide nanoparticles for the detection of breast cancer. The antibody-grafted iron oxide nanoparticles (PAION-Ab) were about 31.1 nm in diameter. The T2 relaxivity of PAION-Ab was 246 L·mmol-1 · sec-1 greater than that of the commercial product such as Feridex. PAION-Ab showed low cytotoxicity even at relatively high concentrations. Furthermore, Prussian blue staining and in vitro MRI study with SKBR-3, breast cancer cells overexpressing HER2/neu receptors indicated that PAION-Ab exhibited excellent cancer cell detection ability and enhanced signal intensities in the T2-weighted image. | en |
dc.description.sponsorship | This work was supported by the Brain Korea 21 (BK21) Program, Nano R&D Program through the KOSEF funded by the Ministry of Education, Science, and Technology (2002-2002845), and a grant from KRIBB Research Initiative Program. We would like to thank the staff of Chuncheon KBSI for their assistance with the TEM measurements and Ochang KBSI for their assistance with MRI measurements. | en |
dc.language.iso | en_US | en |
dc.publisher | American Chemical Society | en |
dc.title | HER2/neu Antibody Conjugated Poly(amino acid)-Coated Iron Oxide Nanoparticles for Breast Cancer MR Imaging | en |
dc.type | Article | en |
dc.identifier.doi | 10.1021/bm100560m | - |
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