DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vodnala, Nagaraju | ko |
dc.contributor.author | Gujjarappa, Raghuram | ko |
dc.contributor.author | Hazra, Chinmoy K. | ko |
dc.contributor.author | Kaldhi, Dhananjaya | ko |
dc.contributor.author | Kabi, Arup. K. | ko |
dc.contributor.author | Beifuss, Uwe | ko |
dc.contributor.author | Malakar, Chandi C. | ko |
dc.date.accessioned | 2019-02-20T04:45:35Z | - |
dc.date.available | 2019-02-20T04:45:35Z | - |
dc.date.created | 2019-01-28 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | ADVANCED SYNTHESIS & CATALYSIS, v.361, no.1, pp.135 - 145 | - |
dc.identifier.issn | 1615-4150 | - |
dc.identifier.uri | http://hdl.handle.net/10203/250164 | - |
dc.description.abstract | A copper-catalyzed approach for the N-acylation of anilines with acetone and acetophenones via C-C bond cleavage is described. Under the developed conditions both CHCl3 and CH2Cl2 were identified as potential C1-source to promote the transformation. The reaction features a site selective C-C bond cleavage to install the amide moieties with high functional-group compatibility and wide substrate scope. The developed method avoids the use of sensitive and narcotic agents. The method also represents an excellent complement to the previous protocols with lower E-factor (13.91 mg/1 mg) than current industrially used method (E-factor 17.54 mg/1 mg). The developed approach has also been extended for the effective preparation of pyridine derivatives and paracetamol in gram scale. The course of the reaction was monitored by H-1 NMR as a preliminary investigation of the reaction mechanism. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Copper-Catalyzed Site-Selective Oxidative C-C Bond Cleavage of Simple Ketones for the Synthesis of Anilides and Paracetamol | - |
dc.type | Article | - |
dc.identifier.wosid | 000455542500016 | - |
dc.identifier.scopusid | 2-s2.0-85057455748 | - |
dc.type.rims | ART | - |
dc.citation.volume | 361 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 135 | - |
dc.citation.endingpage | 145 | - |
dc.citation.publicationname | ADVANCED SYNTHESIS & CATALYSIS | - |
dc.identifier.doi | 10.1002/adsc.201801096 | - |
dc.contributor.nonIdAuthor | Vodnala, Nagaraju | - |
dc.contributor.nonIdAuthor | Gujjarappa, Raghuram | - |
dc.contributor.nonIdAuthor | Kaldhi, Dhananjaya | - |
dc.contributor.nonIdAuthor | Kabi, Arup. K. | - |
dc.contributor.nonIdAuthor | Beifuss, Uwe | - |
dc.contributor.nonIdAuthor | Malakar, Chandi C. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
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