14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization

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dc.contributor.authorTak, Hee-Jaeko
dc.contributor.authorJang, Eun-Sunko
dc.contributor.authorKim, Seung-Beomko
dc.contributor.authorPark, Jin-Hwiko
dc.contributor.authorSuk, Jin-Kyuko
dc.contributor.authorYoon, Yoo-Sikko
dc.contributor.authorAhn, Jeong-Keunko
dc.contributor.authorLee, Jeung-Hoonko
dc.contributor.authorJoe, Cheol-Oko
dc.date.accessioned2011-08-30-
dc.date.available2011-08-30-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-11-
dc.identifier.citationCELLULAR SIGNALLING, v.19, no.11, pp.2379 - 2387-
dc.identifier.issn0898-6568-
dc.identifier.urihttp://hdl.handle.net/10203/25013-
dc.description.abstractThe signal pathway by which 14-3-3 epsilon inhibits cell migration induced by MAPK-activated protein kinase 5 (MK5) was investigated in cultured HeLa cells. Both in vivo and in vitro analyses have revealed that 14-3-3e interacts with MK5. 14-3-3e bound to MK5 inhibits the pbosphorylation of HSP27, a known substrate of MK5. Disturbance of actin cytoskeleton organization by 14-3-3 epsilon was shown in transfected cells transiently expressing 14-3-3 epsilon as well as established cells stably expressing 14-3-3e. Moreover, overexpression of 14-3-3e resulted in the inhibition of cell migration induced by MK5 overexpression or TNF alpha treatment. Our results suggest that 14-3-3 epsilon bound to MK5 inhibits cell migration by inhibiting the phosphorylation of HSP27 whose phospborylation regulates F-actin polymerization, actin cytoskeleton organization and subsequent actinfilament dynamics. (C) 2007 Elsevier Inc. All rights reserved.-
dc.description.sponsorshipThis work was supported by grants from the Korea Science and Engineering Foundation (R01-2006-000-10667-0 and M104010-0002-706N010002710) and the Korea Research Foundation (2005-070-C00105).en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherElsevier Science Inc-
dc.subjectP38 MAP KINASE-
dc.subject14-3-3 PROTEINS-
dc.subjectHEAT-SHOCK-
dc.subjectNUCLEAR-LOCALIZATION-
dc.subjectPHOSPHORYLATION-
dc.subjectACTIVATION-
dc.subjectDYNAMICS-
dc.subjectHSP27-
dc.subjectBINDING-
dc.subjectDEATH-
dc.title14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization-
dc.typeArticle-
dc.identifier.wosid000250026300018-
dc.identifier.scopusid2-s2.0-34548411669-
dc.type.rimsART-
dc.citation.volume19-
dc.citation.issue11-
dc.citation.beginningpage2379-
dc.citation.endingpage2387-
dc.citation.publicationnameCELLULAR SIGNALLING-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorJoe, Cheol-O-
dc.contributor.nonIdAuthorTak, Hee-Jae-
dc.contributor.nonIdAuthorJang, Eun-Sun-
dc.contributor.nonIdAuthorKim, Seung-Beom-
dc.contributor.nonIdAuthorPark, Jin-Hwi-
dc.contributor.nonIdAuthorYoon, Yoo-Sik-
dc.contributor.nonIdAuthorAhn, Jeong-Keun-
dc.contributor.nonIdAuthorLee, Jeung-Hoon-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorMAPK-
dc.subject.keywordAuthorMK5-
dc.subject.keywordAuthor14-3-3 epsilon-
dc.subject.keywordAuthorHSP27-
dc.subject.keywordAuthoractin polymerization-
dc.subject.keywordAuthorcell migration-
dc.subject.keywordAuthorTNF alpha-
dc.subject.keywordPlusP38 MAP KINASE-
dc.subject.keywordPlus14-3-3 PROTEINS-
dc.subject.keywordPlusHEAT-SHOCK-
dc.subject.keywordPlusNUCLEAR-LOCALIZATION-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusDYNAMICS-
dc.subject.keywordPlusHSP27-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusDEATH-
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