DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tak, Hee-Jae | ko |
dc.contributor.author | Jang, Eun-Sun | ko |
dc.contributor.author | Kim, Seung-Beom | ko |
dc.contributor.author | Park, Jin-Hwi | ko |
dc.contributor.author | Suk, Jin-Kyu | ko |
dc.contributor.author | Yoon, Yoo-Sik | ko |
dc.contributor.author | Ahn, Jeong-Keun | ko |
dc.contributor.author | Lee, Jeung-Hoon | ko |
dc.contributor.author | Joe, Cheol-O | ko |
dc.date.accessioned | 2011-08-30 | - |
dc.date.available | 2011-08-30 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | CELLULAR SIGNALLING, v.19, no.11, pp.2379 - 2387 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | http://hdl.handle.net/10203/25013 | - |
dc.description.abstract | The signal pathway by which 14-3-3 epsilon inhibits cell migration induced by MAPK-activated protein kinase 5 (MK5) was investigated in cultured HeLa cells. Both in vivo and in vitro analyses have revealed that 14-3-3e interacts with MK5. 14-3-3e bound to MK5 inhibits the pbosphorylation of HSP27, a known substrate of MK5. Disturbance of actin cytoskeleton organization by 14-3-3 epsilon was shown in transfected cells transiently expressing 14-3-3 epsilon as well as established cells stably expressing 14-3-3e. Moreover, overexpression of 14-3-3e resulted in the inhibition of cell migration induced by MK5 overexpression or TNF alpha treatment. Our results suggest that 14-3-3 epsilon bound to MK5 inhibits cell migration by inhibiting the phosphorylation of HSP27 whose phospborylation regulates F-actin polymerization, actin cytoskeleton organization and subsequent actinfilament dynamics. (C) 2007 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This work was supported by grants from the Korea Science and Engineering Foundation (R01-2006-000-10667-0 and M104010-0002-706N010002710) and the Korea Research Foundation (2005-070-C00105). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Science Inc | - |
dc.subject | P38 MAP KINASE | - |
dc.subject | 14-3-3 PROTEINS | - |
dc.subject | HEAT-SHOCK | - |
dc.subject | NUCLEAR-LOCALIZATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ACTIVATION | - |
dc.subject | DYNAMICS | - |
dc.subject | HSP27 | - |
dc.subject | BINDING | - |
dc.subject | DEATH | - |
dc.title | 14-3-3epsilon inhibits MK5-mediated cell migration by disrupting F-actin polymerization | - |
dc.type | Article | - |
dc.identifier.wosid | 000250026300018 | - |
dc.identifier.scopusid | 2-s2.0-34548411669 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2379 | - |
dc.citation.endingpage | 2387 | - |
dc.citation.publicationname | CELLULAR SIGNALLING | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Joe, Cheol-O | - |
dc.contributor.nonIdAuthor | Tak, Hee-Jae | - |
dc.contributor.nonIdAuthor | Jang, Eun-Sun | - |
dc.contributor.nonIdAuthor | Kim, Seung-Beom | - |
dc.contributor.nonIdAuthor | Park, Jin-Hwi | - |
dc.contributor.nonIdAuthor | Yoon, Yoo-Sik | - |
dc.contributor.nonIdAuthor | Ahn, Jeong-Keun | - |
dc.contributor.nonIdAuthor | Lee, Jeung-Hoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | MK5 | - |
dc.subject.keywordAuthor | 14-3-3 epsilon | - |
dc.subject.keywordAuthor | HSP27 | - |
dc.subject.keywordAuthor | actin polymerization | - |
dc.subject.keywordAuthor | cell migration | - |
dc.subject.keywordAuthor | TNF alpha | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | 14-3-3 PROTEINS | - |
dc.subject.keywordPlus | HEAT-SHOCK | - |
dc.subject.keywordPlus | NUCLEAR-LOCALIZATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | HSP27 | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DEATH | - |
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