DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | ko |
dc.contributor.author | Jeong, JR | ko |
dc.contributor.author | Shin, Sung-Chul | ko |
dc.contributor.author | Huh, YM | ko |
dc.contributor.author | Song, HT | ko |
dc.contributor.author | Suh, JS | ko |
dc.contributor.author | Chang, YH | ko |
dc.contributor.author | Jeon, BS | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2011-08-10T04:45:56Z | - |
dc.date.available | 2011-08-10T04:45:56Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-05 | - |
dc.identifier.citation | JOURNAL OF APPLIED PHYSICS, v.97, pp.1052 - 1057 | - |
dc.identifier.issn | 0021-8979 | - |
dc.identifier.uri | http://hdl.handle.net/10203/24822 | - |
dc.description.abstract | In this study, we propose the use of iron oxide nanoparticle encapsulated with peptide-conjugated poly(D,L lactide-co-glycolide) (PLGA) as a potent intracellular carrier for diagnosis agent. The iron oxide (gamma-Fe2O3) nanoparticles were prepared by a chemical coprecipitation method of ferric and ferrous ions in an alkali solution. Arg peptide (RRRRRRRRCK-FITC) were conjugated to the PLGA via a simple coupling reaction between maleimide-derivatized PLGA and thiol-terminated Arg peptide. The gamma-Fe2O3-PLGA-Arg-FITC nanoparticle was then prepared by an emulsification-diffusion technique. A confocal laser scanning microscopy revealed that the gamma-Fe2O3-PLGA-Arg-FITC nanoparticle was effectively adsorbed onto the membrane of stem cells and delivered into the nuclei without cytotoxicity. Magnetic properties of the gamma-Fe2O3-PLGA-Arg-FITC nanoparticle were observed by measuring the zero-field-cooled/field-cooled magnetization and magnetic hysteresis loop using a superconducting quantum interference device magnetometer from 5 K to 300 K. (c) 2005 American Institute of Physics. | - |
dc.description.sponsorship | This research was partially supported by Center for Ultramicrochemical Process Systems project and by Ministry of Science & Technology project through the Creative Research Initiatives Project. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER INST PHYSICS | - |
dc.subject | MAGNETIC-PROPERTIES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | NANOCLUSTERS | - |
dc.title | Intracellular translocation of superparamagnetic iron oxide nanoparticles encapsulated with peptide-conjugated poly(D,L lactide-co-glycolide) | - |
dc.type | Article | - |
dc.identifier.wosid | 000230168500309 | - |
dc.identifier.scopusid | 2-s2.0-20944443465 | - |
dc.type.rims | ART | - |
dc.citation.volume | 97 | - |
dc.citation.beginningpage | 1052 | - |
dc.citation.endingpage | 1057 | - |
dc.citation.publicationname | JOURNAL OF APPLIED PHYSICS | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Shin, Sung-Chul | - |
dc.contributor.localauthor | Chang, YH | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.nonIdAuthor | Lee, SJ | - |
dc.contributor.nonIdAuthor | Jeong, JR | - |
dc.contributor.nonIdAuthor | Huh, YM | - |
dc.contributor.nonIdAuthor | Song, HT | - |
dc.contributor.nonIdAuthor | Suh, JS | - |
dc.contributor.nonIdAuthor | Jeon, BS | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordPlus | MAGNETIC-PROPERTIES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | NANOCLUSTERS | - |
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