DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Chan-Woo | ko |
dc.contributor.author | Lee, Hyun-Jin | ko |
dc.contributor.author | Yang, Hee-Man | ko |
dc.contributor.author | Woo, Min-Ah | ko |
dc.contributor.author | Park, Hyun Gyu | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2011-08-10T01:37:27Z | - |
dc.date.available | 2011-08-10T01:37:27Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, v.49, no.1, pp.203 - 210 | - |
dc.identifier.issn | 0887-624X | - |
dc.identifier.uri | http://hdl.handle.net/10203/24813 | - |
dc.description.abstract | We developed a simple route to prepare stabilized micelles and nanovesicles in aqueous solutions. A hydrophobic poly(succinimide) (PSI) was conjugated with the hydrophilic poly(ethylene glycol) (PEG) as a new type of cross-linkable unit. Spherical aggregates were formed when dissolving the amphiphilic PEG(682)-b-PSI(130) copolymer in aqueous solutions directly, and polymer nanovesicles were prepared by a precipitation-dialysis method using PEG(455)-b-PSI(130) copolymer. Bifunctional primary amine was added to the micelle or nano-vesicle solutions to prepare cross-linked structures via aminolysis reaction of the succinimide units. The degree of cross-linking was controlled by adjusting the molar ratio of the cross-linker to the succinimide units. Increasing the degree of cross-linking leads to the compaction of the micelle core thus reduced diameter. The cross-linked polymer micelles or nanovesicles maintained their morphology in extremely diluted solutions because of their structural stability. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 203-210, 2011 | - |
dc.description.sponsorship | This work was financially supported by Center for Ultramicrochemical Process Systems, Nano R&D Program of KOSEF, and Korea Research Institute of Bioscience and Biotechnology. The authors thank the staff of KBSI for their assistance with the transmission electron microscopy and 1H NMR measurements. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | WILEY-BLACKWELL PUBLISHING | - |
dc.subject | AMPHIPHILIC BLOCK-COPOLYMERS | - |
dc.subject | MULTIPLE MORPHOLOGIES | - |
dc.subject | DIBLOCK COPOLYMERS | - |
dc.subject | POLYMERIC MICELLES | - |
dc.subject | ASPARTAMIDE) | - |
dc.subject | NANOSPHERES | - |
dc.subject | VESICLES | - |
dc.subject | DELIVERY | - |
dc.subject | BEHAVIOR | - |
dc.subject | ACID) | - |
dc.title | Size and Morphology Controllable Core Cross-Linked Self-Aggregates from Poly(ethylene glycol-b-succinimide) Copolymers | - |
dc.type | Article | - |
dc.identifier.wosid | 000286344300022 | - |
dc.identifier.scopusid | 2-s2.0-78649868220 | - |
dc.type.rims | ART | - |
dc.citation.volume | 49 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 203 | - |
dc.citation.endingpage | 210 | - |
dc.citation.publicationname | JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | - |
dc.identifier.doi | 10.1002/pola.24441 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Hyun Gyu | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | block copolymers | - |
dc.subject.keywordAuthor | cross-linking | - |
dc.subject.keywordAuthor | micelles | - |
dc.subject.keywordAuthor | vesicles | - |
dc.subject.keywordPlus | AMPHIPHILIC BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | MULTIPLE MORPHOLOGIES | - |
dc.subject.keywordPlus | DIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | ASPARTAMIDE) | - |
dc.subject.keywordPlus | NANOSPHERES | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | ACID) | - |
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