DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HeungKyu | ko |
dc.contributor.author | Mattei, Lisa M. | ko |
dc.contributor.author | Steinberg, Benjamin E. | ko |
dc.contributor.author | Alberts, Philipp | ko |
dc.contributor.author | Lee, Yun Hee | ko |
dc.contributor.author | Chervonsky, Alexander | ko |
dc.contributor.author | Mizushima, Noboru | ko |
dc.contributor.author | Grinstein, Sergio | ko |
dc.contributor.author | Iwasaki, Akiko | ko |
dc.date.accessioned | 2011-07-22T07:31:06Z | - |
dc.date.available | 2011-07-22T07:31:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | IMMUNITY, v.32, no.2, pp.227 - 239 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/24691 | - |
dc.description.abstract | Autophagy is known to be important in presentation of cytosolic antigens on MHC class II (MHC II). However, the role of autophagic process in antigen presentation in vivo is unclear. Mice with dendritic cell (DC)-conditional deletion in Atg5, a key autophagy gene, showed impaired CD4(+) T cell priming after herpes simplex virus infection and succumbed to rapid disease. The most pronounced defect of Atg5(-/-) DCs was the processing and presentation of phagocytosed antigens containing Toll-like receptor stimuli for MHC class II. In contrast, cross-presentation of peptides on MHC I was intact in the absence of Atg5. Although induction of metabolic autophagy did not enhance MHC II presentation, autophagic machinery was required for optimal phagosome-to-lysosome fusion and subsequent processing of antigen for MHC II loading. Thus, our study revealed that DCs utilize autophagic machinery to optimally process and present extracellular microbial antigens for MHC II presentation. | - |
dc.description.sponsorship | This study was supported by grants from the National Institute of Allergy and Immunology (AI054359, AI062428, and AI064705 to A.I. and AI72627 to A.C.). H.K.L. is a recipient of an Anna Fuller cancer research fellowship and Richard K. Gershon predoctoral training fellowship. A.I. is a recipient of the Burroughs Wellcome Investigators in Pathogenesis of Infectious Disease. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | CELL PRESS | - |
dc.subject | HERPES-SIMPLEX-VIRUS | - |
dc.subject | CLASS-II MOLECULES | - |
dc.subject | CD4(+) T-CELLS | - |
dc.subject | RESTRICTED PRESENTATION | - |
dc.subject | DIFFERENTIAL ROLES | - |
dc.subject | CROSS-PRESENTATION | - |
dc.subject | ADAPTIVE IMMUNITY | - |
dc.subject | AUTOPHAGY PROTEIN | - |
dc.subject | CYTOSOLIC ANTIGEN | - |
dc.subject | TYPE-2 INFECTION | - |
dc.title | In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000275346000012 | - |
dc.identifier.scopusid | 2-s2.0-76949091325 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 227 | - |
dc.citation.endingpage | 239 | - |
dc.citation.publicationname | IMMUNITY | - |
dc.identifier.doi | 10.1016/j.immuni.2009.12.006 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, HeungKyu | - |
dc.contributor.nonIdAuthor | Mattei, Lisa M. | - |
dc.contributor.nonIdAuthor | Steinberg, Benjamin E. | - |
dc.contributor.nonIdAuthor | Alberts, Philipp | - |
dc.contributor.nonIdAuthor | Lee, Yun Hee | - |
dc.contributor.nonIdAuthor | Chervonsky, Alexander | - |
dc.contributor.nonIdAuthor | Mizushima, Noboru | - |
dc.contributor.nonIdAuthor | Grinstein, Sergio | - |
dc.contributor.nonIdAuthor | Iwasaki, Akiko | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | CELLIMMUNO | - |
dc.subject.keywordAuthor | MOLIMMUNO | - |
dc.subject.keywordPlus | HERPES-SIMPLEX-VIRUS | - |
dc.subject.keywordPlus | CLASS-II MOLECULES | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordPlus | RESTRICTED PRESENTATION | - |
dc.subject.keywordPlus | DIFFERENTIAL ROLES | - |
dc.subject.keywordPlus | CROSS-PRESENTATION | - |
dc.subject.keywordPlus | ADAPTIVE IMMUNITY | - |
dc.subject.keywordPlus | AUTOPHAGY PROTEIN | - |
dc.subject.keywordPlus | CYTOSOLIC ANTIGEN | - |
dc.subject.keywordPlus | TYPE-2 INFECTION | - |
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