DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Sung Yoon | ko |
dc.contributor.author | Kim, Byung Hwi | ko |
dc.contributor.author | Huh, Beom Kang | ko |
dc.contributor.author | Jeong, Woong | ko |
dc.contributor.author | Park, Min | ko |
dc.contributor.author | Park, Hyo Jin | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.contributor.author | Heo, Chan Yeong | ko |
dc.contributor.author | Choy, Young Bin | ko |
dc.date.accessioned | 2018-11-22T06:41:19Z | - |
dc.date.available | 2018-11-22T06:41:19Z | - |
dc.date.created | 2018-11-13 | - |
dc.date.created | 2018-11-13 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.67, pp.469 - 477 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/10203/246686 | - |
dc.description.abstract | We describe surgical sutures enabled with the local, sustained delivery of a TGF-beta inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly (lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-beta expression and fibroblast numbers during the entire 21 day testing period. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | GROWTH-FACTORS | - |
dc.subject | FIBROSIS | - |
dc.subject | SKIN | - |
dc.subject | SUPPRESSION | - |
dc.subject | RELEASE | - |
dc.subject | KELOIDS | - |
dc.subject | MODEL | - |
dc.title | Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-beta expression and fibroblast recruitment | - |
dc.type | Article | - |
dc.identifier.wosid | 000448095700047 | - |
dc.identifier.scopusid | 2-s2.0-85050863515 | - |
dc.type.rims | ART | - |
dc.citation.volume | 67 | - |
dc.citation.beginningpage | 469 | - |
dc.citation.endingpage | 477 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jiec.2018.07.021 | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.nonIdAuthor | Choi, Sung Yoon | - |
dc.contributor.nonIdAuthor | Kim, Byung Hwi | - |
dc.contributor.nonIdAuthor | Huh, Beom Kang | - |
dc.contributor.nonIdAuthor | Jeong, Woong | - |
dc.contributor.nonIdAuthor | Park, Min | - |
dc.contributor.nonIdAuthor | Park, Hyo Jin | - |
dc.contributor.nonIdAuthor | Heo, Chan Yeong | - |
dc.contributor.nonIdAuthor | Choy, Young Bin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Fibroblasts | - |
dc.subject.keywordAuthor | Scar reduction | - |
dc.subject.keywordAuthor | Surgical suture | - |
dc.subject.keywordAuthor | Sustained drug delivery | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | KELOIDS | - |
dc.subject.keywordPlus | MODEL | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.