DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Min Hee | ko |
dc.contributor.author | Lee, Ju Youn | ko |
dc.contributor.author | Park, Kang Ho | ko |
dc.contributor.author | Jung, In Kyung | ko |
dc.contributor.author | Kim, Kyoung-Tae | ko |
dc.contributor.author | Lee, Yong-Seok | ko |
dc.contributor.author | Ryu, Hyun-Hee | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.contributor.author | Kang, Minseok | ko |
dc.contributor.author | Schwaninger, Markus | ko |
dc.contributor.author | Gulbins, Erich | ko |
dc.contributor.author | Reichel, Martin | ko |
dc.contributor.author | Kornhuber, Johannes | ko |
dc.contributor.author | Yamaguchi, Tomoyuki | ko |
dc.contributor.author | Kim, Hee Jin | ko |
dc.contributor.author | Kim, Seung Hyun | ko |
dc.contributor.author | Schuchman, Edward H. | ko |
dc.contributor.author | Jin, Hee Kyung | ko |
dc.contributor.author | Bae, Jae-Sung | ko |
dc.date.accessioned | 2018-11-12T04:50:53Z | - |
dc.date.available | 2018-11-12T04:50:53Z | - |
dc.date.created | 2018-10-29 | - |
dc.date.created | 2018-10-29 | - |
dc.date.created | 2018-10-29 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | NEURON, v.100, no.1, pp.167 - + | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/246547 | - |
dc.description.abstract | Although many reports have revealed dysfunction of endothelial cells in aging, resulting in blood-brain barrier (BBB) breakdown, the underlying mechanism or mechanisms remain to be explored. Here, we find that acid sphingomyelinase (ASM) is a critical factor for regulating brain endothelial barrier integrity. ASM is increased in brain endothelium and/or plasma of aged humans and aged mice, leading to BBB disruption by increasing caveolae-mediated transcytosis. Genetic inhibition and endothelial-specific knockdown of ASM in mice ameliorated BBB breakdown and neurocognitive impairment during aging. Using primary mouse brain endothelial cells, we found that ASM regulated the caveolae-cytoskeleton interaction through protein phosphatase 1-mediated ezrin/radixin/moesin (ERM) dephosphorylation and apoptosis. Moreover, mice with conditional ASM overexpression in brain endothelium accelerated significant BBB impairment and neurodegenerative change. Overall, these results reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM | - |
dc.type | Article | - |
dc.identifier.wosid | 000446862000018 | - |
dc.identifier.scopusid | 2-s2.0-85054143700 | - |
dc.type.rims | ART | - |
dc.citation.volume | 100 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 167 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/j.neuron.2018.09.010 | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.nonIdAuthor | Park, Min Hee | - |
dc.contributor.nonIdAuthor | Lee, Ju Youn | - |
dc.contributor.nonIdAuthor | Park, Kang Ho | - |
dc.contributor.nonIdAuthor | Jung, In Kyung | - |
dc.contributor.nonIdAuthor | Kim, Kyoung-Tae | - |
dc.contributor.nonIdAuthor | Lee, Yong-Seok | - |
dc.contributor.nonIdAuthor | Ryu, Hyun-Hee | - |
dc.contributor.nonIdAuthor | Schwaninger, Markus | - |
dc.contributor.nonIdAuthor | Gulbins, Erich | - |
dc.contributor.nonIdAuthor | Reichel, Martin | - |
dc.contributor.nonIdAuthor | Kornhuber, Johannes | - |
dc.contributor.nonIdAuthor | Yamaguchi, Tomoyuki | - |
dc.contributor.nonIdAuthor | Kim, Hee Jin | - |
dc.contributor.nonIdAuthor | Kim, Seung Hyun | - |
dc.contributor.nonIdAuthor | Schuchman, Edward H. | - |
dc.contributor.nonIdAuthor | Jin, Hee Kyung | - |
dc.contributor.nonIdAuthor | Bae, Jae-Sung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | ACID SPHINGOMYELINASE/CERAMIDE PATHWAY | - |
dc.subject.keywordPlus | CAVEOLAE-MEDIATED TRANSCYTOSIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
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