DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Misun | ko |
dc.contributor.author | Kim, Mingeun | ko |
dc.contributor.author | Tikum, Anjong Florence | ko |
dc.contributor.author | Lee, Hyuck Jin | ko |
dc.contributor.author | Thamilarasan, Vijayan | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.contributor.author | Kim, Jinheung | ko |
dc.date.accessioned | 2018-11-12T04:16:51Z | - |
dc.date.available | 2018-11-12T04:16:51Z | - |
dc.date.created | 2018-10-24 | - |
dc.date.created | 2018-10-24 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | DYES AND PIGMENTS, v.162, pp.97 - 103 | - |
dc.identifier.issn | 0143-7208 | - |
dc.identifier.uri | http://hdl.handle.net/10203/246289 | - |
dc.description.abstract | The deposition of amyloid-β (Aβ) aggregates in the brain is a hallmark of the Alzheimer's disease (AD)-affected brain. Various aggregated Aβ species, including oligomers and fibrils, are generated upon the aggregation process, and these Aβ aggregates have distinct biological properties. To non-invasively monitor the aggregation pathways of Aβ and identify the existence of certain Aβ species in biological environments, an effective strategy to detect Aβ species is necessary. Herein, we report a turn-on near-infrared (near-IR) fluorescent probe, 1, for Aβ aggregates, which consists of a donor-π-acceptor system with an Aβ-interacting moiety. Our probe, 1, shows a noticeable increase in near-IR fluorescence at ca. 710 nm in the presence of Aβ aggregates in aqueous media. In addition, the fluorescent response of 1 was altered depending on the degree of Aβ aggregation. Moreover, 1 indicates turn-on fluorescence with Aβ aggregates in living cells and is nontoxic under the condition used for live-cell imaging. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | A near-infrared fluorescent probe for amyloid-beta aggregates | - |
dc.type | Article | - |
dc.identifier.wosid | 000456226500013 | - |
dc.identifier.scopusid | 2-s2.0-85054860215 | - |
dc.type.rims | ART | - |
dc.citation.volume | 162 | - |
dc.citation.beginningpage | 97 | - |
dc.citation.endingpage | 103 | - |
dc.citation.publicationname | DYES AND PIGMENTS | - |
dc.identifier.doi | 10.1016/j.dyepig.2018.10.013 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Lee, Misun | - |
dc.contributor.nonIdAuthor | Kim, Mingeun | - |
dc.contributor.nonIdAuthor | Tikum, Anjong Florence | - |
dc.contributor.nonIdAuthor | Lee, Hyuck Jin | - |
dc.contributor.nonIdAuthor | Thamilarasan, Vijayan | - |
dc.contributor.nonIdAuthor | Kim, Jinheung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
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