DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun Hee | ko |
dc.contributor.author | Jo, Hyelim | ko |
dc.contributor.author | Seo, Hogyu David | ko |
dc.contributor.author | Park, Hee-Sung | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.date.accessioned | 2018-10-19T00:49:46Z | - |
dc.date.available | 2018-10-19T00:49:46Z | - |
dc.date.created | 2018-10-08 | - |
dc.date.created | 2018-10-08 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.503, no.3, pp.1200 - 1206 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/246164 | - |
dc.description.abstract | In Saccharomyces cerevisiae, the ATP-dependent chromatin remodeler, Chd1p, globally affects nucleosome positioning at coding regions, where nucleosomes are specifically and directionally aligned with respect to the transcription start site (TSS). Various auxiliary domains of remodelers play critical roles by performing specialized functions that are unique to the type of remodeler. Here, we report that yeast Chd1p directly binds to acetylated histone H3K36 (H3K36Ac) via its chromodomain, and that H3K36Ac stimulates the nucleosome sliding activity of Chd1p in vitro. Furthermore, we use genome-wide analysis to demonstrate that H3K36Ac promotes the remodeling activity of Chd1p to maintain chromatin stability at the 5' ends of genes in vivo. Our work linking Chd1p with H3K36Ac provides novel insights into how the nucleosome remodeling activity of Chd1p is controlled near the TSS. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SACCHAROMYCES-CEREVISIAE | - |
dc.subject | RECOMBINANT HISTONES | - |
dc.subject | CHROMATIN REMODELER | - |
dc.subject | CHROMODOMAINS | - |
dc.subject | BINDING | - |
dc.subject | HETEROCHROMATIN | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ORGANIZATION | - |
dc.subject | METHYLATION | - |
dc.subject | SWI/SNF | - |
dc.title | Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site | - |
dc.type | Article | - |
dc.identifier.wosid | 000444222100004 | - |
dc.identifier.scopusid | 2-s2.0-85049606448 | - |
dc.type.rims | ART | - |
dc.citation.volume | 503 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 1200 | - |
dc.citation.endingpage | 1206 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.07.025 | - |
dc.contributor.localauthor | Park, Hee-Sung | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Chromatin remodeling | - |
dc.subject.keywordAuthor | Nucleosome sliding | - |
dc.subject.keywordAuthor | H3K36Ac | - |
dc.subject.keywordAuthor | Chd1p | - |
dc.subject.keywordAuthor | Saccharomyces cerevisiae | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | RECOMBINANT HISTONES | - |
dc.subject.keywordPlus | CHROMATIN REMODELER | - |
dc.subject.keywordPlus | CHROMODOMAINS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | HETEROCHROMATIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | SWI/SNF | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.