DC Field | Value | Language |
---|---|---|
dc.contributor.author | Upla, Paula | ko |
dc.contributor.author | Kim, Seung Joong | ko |
dc.contributor.author | Sampathkumar, Parthasarathy | ko |
dc.contributor.author | Dutta, Kaushik | ko |
dc.contributor.author | Cahill, Sean M. | ko |
dc.contributor.author | Chemmama, Ilan E. | ko |
dc.contributor.author | Williams, Rosemary | ko |
dc.contributor.author | Bonanno, Jeffrey B. | ko |
dc.contributor.author | Rice, William J. | ko |
dc.contributor.author | Stokes, David L. | ko |
dc.contributor.author | Cowburn, David | ko |
dc.contributor.author | Almo, Steven C. | ko |
dc.contributor.author | Sali, Andrej | ko |
dc.contributor.author | Rout, Michael P. | ko |
dc.contributor.author | Fernandez-Martinez, Javier | ko |
dc.date.accessioned | 2018-10-19T00:42:43Z | - |
dc.date.available | 2018-10-19T00:42:43Z | - |
dc.date.created | 2018-10-01 | - |
dc.date.created | 2018-10-01 | - |
dc.date.created | 2018-10-01 | - |
dc.date.created | 2018-10-01 | - |
dc.date.created | 2018-10-01 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | STRUCTURE, v.25, no.3, pp.434 - 445 | - |
dc.identifier.issn | 0969-2126 | - |
dc.identifier.uri | http://hdl.handle.net/10203/246055 | - |
dc.description.abstract | The membrane ring that equatorially circumscribes the nuclear pore complex (NPC) in the perinuclear lumen of the nuclear envelope is composed largely of Pom152 in yeast and its ortholog Nup210 (or Gp210) in vertebrates. Here, we have used a combination of negative-stain electron microscopy, nuclear magnetic resonance, and small-angle X-ray scattering methods to determine an integrative structure of the similar to 120 kDa luminal domain of Pom152. Our structural analysis reveals that the luminal domain is formed by a flexible string-ofpearls arrangement of nine repetitive cadherin-like Ig-like domains, indicating an evolutionary connection between NPCs and the cell adhesion machinery. The 16 copies of Pom152 known to be present in the yeast NPC are long enough to form the observed membrane ring, suggesting how interactions between Pom152 molecules help establish and maintain the NPC architecture. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex | - |
dc.type | Article | - |
dc.identifier.wosid | 000396703500005 | - |
dc.identifier.scopusid | 2-s2.0-85011298969 | - |
dc.type.rims | ART | - |
dc.citation.volume | 25 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 434 | - |
dc.citation.endingpage | 445 | - |
dc.citation.publicationname | STRUCTURE | - |
dc.identifier.doi | 10.1016/j.str.2017.01.006 | - |
dc.contributor.localauthor | Kim, Seung Joong | - |
dc.contributor.nonIdAuthor | Upla, Paula | - |
dc.contributor.nonIdAuthor | Sampathkumar, Parthasarathy | - |
dc.contributor.nonIdAuthor | Dutta, Kaushik | - |
dc.contributor.nonIdAuthor | Cahill, Sean M. | - |
dc.contributor.nonIdAuthor | Chemmama, Ilan E. | - |
dc.contributor.nonIdAuthor | Williams, Rosemary | - |
dc.contributor.nonIdAuthor | Bonanno, Jeffrey B. | - |
dc.contributor.nonIdAuthor | Rice, William J. | - |
dc.contributor.nonIdAuthor | Stokes, David L. | - |
dc.contributor.nonIdAuthor | Cowburn, David | - |
dc.contributor.nonIdAuthor | Almo, Steven C. | - |
dc.contributor.nonIdAuthor | Sali, Andrej | - |
dc.contributor.nonIdAuthor | Rout, Michael P. | - |
dc.contributor.nonIdAuthor | Fernandez-Martinez, Javier | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CELL-CELL ADHESION | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | MACROMOLECULAR ASSEMBLIES | - |
dc.subject.keywordPlus | HEPTAMERIC MODULE | - |
dc.subject.keywordPlus | TARGETING DOMAIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | ENVELOPE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.