DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Jinhyo | ko |
dc.contributor.author | Kim, Kyeong Hu | ko |
dc.contributor.author | Choe, Kibaek | ko |
dc.contributor.author | Lim, Joo Hyuck | ko |
dc.contributor.author | Lee, Seung Ki | ko |
dc.contributor.author | Kim, Yeon Sook | ko |
dc.contributor.author | Kim, Pilhan | ko |
dc.date.accessioned | 2018-08-20T08:07:10Z | - |
dc.date.available | 2018-08-20T08:07:10Z | - |
dc.date.created | 2018-08-13 | - |
dc.date.created | 2018-08-13 | - |
dc.date.created | 2018-08-13 | - |
dc.date.created | 2018-08-13 | - |
dc.date.created | 2018-08-13 | - |
dc.date.created | 2018-08-13 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | BIOMEDICAL OPTICS EXPRESS, v.9, no.8 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244957 | - |
dc.description.abstract | Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively. Permeability analysis of many delivering agents has been mostly conducted by a simple tape stripping method. However, it cannot reveal a detailed depth-dependent distribution profile of transdermally delivered agents in the skin. In this work, we achieved a cellular-level depth-defined visualization of fluorophore-labelled human epidermal growth factor (EGF) transdermally delivered to human skin by using encapsulation with common liposomes and newly fabricated multi-lamellar nanostructures using a custom-design two-photon microscopy system. It was able to generate 3D reconstructed images displaying the distribution of human EGF inside the human skin sample with high-resolution. Based on a depthwise fluorescence intensity profile showing the permeation of human EGF, a quantitative analysis was performed to assess the transdermal delivery efficacy achieved by each formulation, showing a significant improvement of the efficacy with the utilization of multi-lamellar nanostructure. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement | - |
dc.language | English | - |
dc.publisher | OPTICAL SOC AMER | - |
dc.title | Quantitative two-photon microscopy imaging analysis of human skin to evaluate enhanced transdermal delivery by hybrid-type multi-lamellar nanostructure | - |
dc.type | Article | - |
dc.identifier.wosid | 000440490500036 | - |
dc.identifier.scopusid | 2-s2.0-85051288097 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 8 | - |
dc.citation.publicationname | BIOMEDICAL OPTICS EXPRESS | - |
dc.identifier.doi | 10.1364/BOE.9.003974 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Pilhan | - |
dc.contributor.nonIdAuthor | Kim, Kyeong Hu | - |
dc.contributor.nonIdAuthor | Lim, Joo Hyuck | - |
dc.contributor.nonIdAuthor | Lee, Seung Ki | - |
dc.contributor.nonIdAuthor | Kim, Yeon Sook | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ENCAPSULATION EFFICIENCY | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | EX-VIVO | - |
dc.subject.keywordPlus | PENETRATION | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | PERMEATION | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | VITRO | - |
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