DC Field | Value | Language |
---|---|---|
dc.contributor.author | Um, Seung Min | ko |
dc.contributor.author | Ha, Seungmin | ko |
dc.contributor.author | Lee, Hyejin | ko |
dc.contributor.author | Kim, Jihye | ko |
dc.contributor.author | Kim, Kyungdeok | ko |
dc.contributor.author | Shin, Wangyong | ko |
dc.contributor.author | Cho, Yi Sul | ko |
dc.contributor.author | Roh, Junyeop D | ko |
dc.contributor.author | Kang, Jaeseung | ko |
dc.contributor.author | Yoo, Taesun | ko |
dc.contributor.author | Noh, Young Woo | ko |
dc.contributor.author | Choi, Yeonsoo | ko |
dc.contributor.author | Bae, Yong Chul | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2018-08-20T07:54:38Z | - |
dc.date.available | 2018-08-20T07:54:38Z | - |
dc.date.created | 2018-08-01 | - |
dc.date.created | 2018-08-01 | - |
dc.date.created | 2018-08-01 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | CELL REPORTS, v.23, no.13, pp.3839 - 3851 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244900 | - |
dc.description.abstract | Netrin-G ligand 2 (NGL-2)/LRRC4, implicated in autism spectrum disorders and schizophrenia, is a leucine-rich repeat-containing postsynaptic adhesion molecule that interacts intracellularly with the excitatory postsynaptic scaffolding protein PSD-95 and trans-synaptically with the presynaptic adhesion molecule netrin-G2. Functionally, NGL-2 regulates excitatory synapse development and synaptic transmission. However, whether it regulates synaptic plasticity and disease-related specific behaviors is not known. Here, we report that mice lacking NGL-2 (Lrrc4(-/-) mice) show suppressed N-MethylD-aspartate receptor (NMDAR)-dependent synaptic plasticity in the hippocampus. NGL-2 associates with NMDARs through both PSD-95-dependent and -independent mechanisms. Moreover, Lrrc4(-/-) mice display mild social interaction deficits and repetitive behaviors that are rapidly improved by pharmacological NMDAR activation. These results suggest that NGL-2 promotes synaptic stabilization of NMDARs, regulates NMDAR-dependent synaptic plasticity, and prevents autistic-like behaviors from developing in mice, supporting the hypothesis that NMDAR dysfunction contributes to autism spectrum disorders. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation | - |
dc.type | Article | - |
dc.identifier.wosid | 000436517100015 | - |
dc.identifier.scopusid | 2-s2.0-85048396595 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 13 | - |
dc.citation.beginningpage | 3839 | - |
dc.citation.endingpage | 3851 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2018.05.087 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Lee, Hyejin | - |
dc.contributor.nonIdAuthor | Kim, Jihye | - |
dc.contributor.nonIdAuthor | Cho, Yi Sul | - |
dc.contributor.nonIdAuthor | Kang, Jaeseung | - |
dc.contributor.nonIdAuthor | Noh, Young Woo | - |
dc.contributor.nonIdAuthor | Bae, Yong Chul | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CYCLOSERINE IMPROVES SOCIABILITY | - |
dc.subject.keywordPlus | SYNAPTIC ADHESION MOLECULES | - |
dc.subject.keywordPlus | INBRED MOUSE STRAINS | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | RECEPTOR HYPOFUNCTION | - |
dc.subject.keywordPlus | SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | ULTRASONIC VOCALIZATIONS | - |
dc.subject.keywordPlus | STEREOTYPIC BEHAVIORS | - |
dc.subject.keywordPlus | SHANK3 DEFICIENCY | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
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