DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Han Beom | ko |
dc.contributor.author | Kim, Hyun Nam | ko |
dc.contributor.author | Lee, Ju Hyuk | ko |
dc.contributor.author | Lee, Ik Jae | ko |
dc.contributor.author | Choi, Jinhyun | ko |
dc.contributor.author | Cho, Sung Oh | ko |
dc.date.accessioned | 2018-08-20T07:47:02Z | - |
dc.date.available | 2018-08-20T07:47:02Z | - |
dc.date.created | 2018-08-06 | - |
dc.date.created | 2018-08-06 | - |
dc.date.created | 2018-08-06 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | NUCLEAR ENGINEERING AND TECHNOLOGY, v.50, no.6, pp.937 - 943 | - |
dc.identifier.issn | 1738-5733 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244812 | - |
dc.description.abstract | Background: This work presents the performance of a novel electronic brachytherapy (EBT) device and radiotherapy (RT) experiments on both skin cancer cells and animals using the device. Methods and materials: The performance of the EBT device was evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells was analyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice. Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. The results of the RT experiments on the skin cancer cells show that a significant apoptosis induction occurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results of the animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growth and that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same as that induced by irradiation with a high-energy electron beam. Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancer with a conventional linear accelerator. Consequently, the EBT device can be practically used for human skin cancer treatment in the near future. (C) 2018 Korean Nuclear Society, Published by Elsevier Korea LLC. | - |
dc.language | English | - |
dc.publisher | KOREAN NUCLEAR SOC | - |
dc.title | Dosimetric characterization and commissioning of a superficial electronic brachytherapy device for skin cancer treatment | - |
dc.type | Article | - |
dc.identifier.wosid | 000439417300017 | - |
dc.identifier.scopusid | 2-s2.0-85046807158 | - |
dc.type.rims | ART | - |
dc.citation.volume | 50 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 937 | - |
dc.citation.endingpage | 943 | - |
dc.citation.publicationname | NUCLEAR ENGINEERING AND TECHNOLOGY | - |
dc.identifier.doi | 10.1016/j.net.2018.04.007 | - |
dc.contributor.localauthor | Cho, Sung Oh | - |
dc.contributor.nonIdAuthor | Park, Han Beom | - |
dc.contributor.nonIdAuthor | Lee, Ik Jae | - |
dc.contributor.nonIdAuthor | Choi, Jinhyun | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Carbon Nanotube | - |
dc.subject.keywordAuthor | Electronic Brachytherapy | - |
dc.subject.keywordAuthor | Miniature X-ray Tube | - |
dc.subject.keywordAuthor | Radiotherapy Experiments | - |
dc.subject.keywordAuthor | Skin Cancer | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | CARCINOMAS | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | PINNA | - |
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