Visible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles

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dc.contributor.authorHeo, Nam Suko
dc.contributor.authorLee, Sun Ukko
dc.contributor.authorRethinasabapathy, Murugananthamko
dc.contributor.authorLee, Eun Zooko
dc.contributor.authorCho, Hye-Jinko
dc.contributor.authorOh, Seo Yeongko
dc.contributor.authorChoe, Sang Rakko
dc.contributor.authorKim, Yeonhoko
dc.contributor.authorHong, Won G.ko
dc.contributor.authorKrishnan, Giribabuko
dc.contributor.authorHong, Won Hiko
dc.contributor.authorJeon, Tae-Joonko
dc.contributor.authorJun, Young-Siko
dc.contributor.authorKim, Hae Jinko
dc.contributor.authorHuh, Yun Sukko
dc.date.accessioned2018-08-20T06:48:02Z-
dc.date.available2018-08-20T06:48:02Z-
dc.date.created2018-07-25-
dc.date.created2018-07-25-
dc.date.issued2018-09-
dc.identifier.citationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.90, pp.531 - 538-
dc.identifier.issn0928-4931-
dc.identifier.urihttp://hdl.handle.net/10203/244648-
dc.description.abstractOrganic graphitic carbon nitride nanoparticles (NP-g-CN), less than 30 nm in size, were synthesized and evaluated for photodynamic therapy (PDT) and cell imaging applications. NP-g-CN particles were prepared through an intercalation process using a rod-like melamine-cyanuric acid adduct (MCA) as the molecular precursor and a eutectic mixture of LiCI-KCI (45:55 wt%) as the reaction medium for polycondensation. The nano-dimensional NP-g-CN penetrated the malignant tumor cells with minimal hindrance and effectively generated reactive oxygen species (ROS) under visible light irradiation, which could ablate cancer cells. When excited by visible light irradiation (lambda > 420 nm), NP-g-CN introduced to HeLa and cos-7 cells generated a significant amount of ROS and killed the cancerous cells selectively. The cytotoxicity of NP-g-CN was manipulated by altering the light irradiation and the BP-g-CN caused more damage to the cancer cells than normal cells at low concentrations. As a potential non-toxic organic nanomaterial, the synthesized NP-g-CN are biocompatible with less cytotoxicity than toxic inorganic materials. The combined effects of the high efficacy of ROS generation under visible light irradiation, low toxicity, and bio-compatibility highlight the potential of NP-g-CN for PDT and imaging without further modification.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectPHOTODYNAMIC THERAPY-
dc.subjectCONVERSION-
dc.subjectNANOPLATFORM-
dc.subjectNANOSHEETS-
dc.subjectPORPHYRIN-
dc.subjectMELAMINE-
dc.titleVisible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles-
dc.typeArticle-
dc.identifier.wosid000435619600057-
dc.identifier.scopusid2-s2.0-85046667091-
dc.type.rimsART-
dc.citation.volume90-
dc.citation.beginningpage531-
dc.citation.endingpage538-
dc.citation.publicationnameMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS-
dc.identifier.doi10.1016/j.msec.2018.04.035-
dc.contributor.localauthorHong, Won Hi-
dc.contributor.nonIdAuthorHeo, Nam Su-
dc.contributor.nonIdAuthorLee, Sun Uk-
dc.contributor.nonIdAuthorRethinasabapathy, Muruganantham-
dc.contributor.nonIdAuthorLee, Eun Zoo-
dc.contributor.nonIdAuthorCho, Hye-Jin-
dc.contributor.nonIdAuthorOh, Seo Yeong-
dc.contributor.nonIdAuthorChoe, Sang Rak-
dc.contributor.nonIdAuthorKim, Yeonho-
dc.contributor.nonIdAuthorHong, Won G.-
dc.contributor.nonIdAuthorKrishnan, Giribabu-
dc.contributor.nonIdAuthorJeon, Tae-Joon-
dc.contributor.nonIdAuthorJun, Young-Si-
dc.contributor.nonIdAuthorKim, Hae Jin-
dc.contributor.nonIdAuthorHuh, Yun Suk-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorGraphitic carbon nitride-
dc.subject.keywordAuthorPhoto dynamic therapy-
dc.subject.keywordAuthorBio-imaging-
dc.subject.keywordAuthorCytotoxicity-
dc.subject.keywordAuthorReactive oxygen species-
dc.subject.keywordPlusPHOTODYNAMIC THERAPY-
dc.subject.keywordPlusCONVERSION-
dc.subject.keywordPlusNANOPLATFORM-
dc.subject.keywordPlusNANOSHEETS-
dc.subject.keywordPlusPORPHYRIN-
dc.subject.keywordPlusMELAMINE-
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