DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Jimyung | ko |
dc.contributor.author | Kim, Joon | ko |
dc.date.accessioned | 2018-07-24T01:38:22Z | - |
dc.date.available | 2018-07-24T01:38:22Z | - |
dc.date.created | 2018-06-25 | - |
dc.date.created | 2018-06-25 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | BMB REPORTS, v.51, no.3, pp.151 - 156 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | http://hdl.handle.net/10203/243706 | - |
dc.description.abstract | The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actin-mediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain. | - |
dc.language | English | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Regulation of Hippo signaling by actin remodeling | - |
dc.type | Article | - |
dc.identifier.wosid | 000434112800007 | - |
dc.identifier.scopusid | 2-s2.0-85044663974 | - |
dc.type.rims | ART | - |
dc.citation.volume | 51 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 151 | - |
dc.citation.endingpage | 156 | - |
dc.citation.publicationname | BMB REPORTS | - |
dc.identifier.doi | 10.5483/BMBRep.2018.51.3.012 | - |
dc.contributor.localauthor | Kim, Joon | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Review | - |
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