DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Hee Seung | - |
dc.contributor.advisor | 이희승 | - |
dc.contributor.author | Jeon, Myo Bin | - |
dc.date.accessioned | 2018-06-20T06:26:21Z | - |
dc.date.available | 2018-06-20T06:26:21Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718754&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/243585 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2017.8,[iv, 46 p. :] | - |
dc.description.abstract | The design and synthesis of artificial materials that mimic sophisticated and complex natural system is an important challenge in synthetic chemistry and biology. In this thesis, we designed a novel strategy for $C_3$-symmetric and $C_2$-symmetric building blocks which have conjugate secondary structures (i.e. tertiary structure) by connecting two or more peptide foldamers to a specific linker motif and obtained more complex hierarchical self-assembled structures from newly designed building blocks. We synthesized helix-linker-helix conjugated building blocks by connecting amide bonds with helical beta-peptide which is known to form stable 12-helical structure and benzene or alkene linker which has fixed orientation. We obtained foldectures from foldamer-conjugate building blocks by aqueous self-assembly and observed nanospheres, nanodiscs, and rectangular plates shapes at each building units. It means that the macroscopic 3D shapes of the foldectures changes as the structural parameters of foldamer-conjugate building blocks. We expect that the study of self-assembly of helix-linker-helix building units can play a key role to elucidate the information of hierarchical self-assembly of protein molecules. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Self-assembly▼a$\beta$-peptide foldamer▼a$C_3$-symmetric building block▼a$C_2$-symmetric building block▼amolecular-level design | - |
dc.subject | 자기조립▼a베타-펩타이드 폴대머▼a$C_3$-대칭형 단위체▼a$C_2$-대칭형 단위체▼a분자 수준 설계 | - |
dc.title | Design and synthesis of 3D organic molecular architectures from self-assembly of helical foldamers conjugated to rigid linker | - |
dc.title.alternative | 견고한 링커로 연결된 나선형 폴대머의 자기조립 조절을 통한 삼차원 유기분자구조체 설계 및 합성에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 전묘빈 | - |
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