DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Chan Beum | - |
dc.contributor.advisor | 박찬범 | - |
dc.contributor.author | Son, Giyeong | - |
dc.date.accessioned | 2018-06-20T06:19:33Z | - |
dc.date.available | 2018-06-20T06:19:33Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=675263&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/243136 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 신소재공학과, 2017.2,[vi, 47 p. :] | - |
dc.description.abstract | Ruthenium (II) complexes are visible light-active photocatalyst extensively used for solar energy harvesting and conversion applications. Here, we report our finding that tris(2,2-bipyridine) ruthenium(II) $[Ru(bpy)_3^{2+}]$ can function as a highly sensitive, biocompatible agent for anti-amyloidgenesis. The abnormal aggregation of β-amyloid (Aβ) peptides is a major pathological hallmark of Alzheimer's disease. According to our multiple analyses, visible light-induced $Ru(bpy)_3^{2+}$ successfully disassembles preformed Aβ aggregates into non-fibrillar aggregates by destructing β-sheet structures. Moreover, we identified the changes of solubility and diameter of the disassembled A? aggregates and photo-degradation of small oligomers including trimeric, tetrameric species. We also validated that photoexcited $Ru(bpy)_3^{2+}$ can cleave peptide bonds in Aβ using mass spectroscopy. The efficacy of $Ru(bpy)_3^{2+}$ is derived from photon-energy in visible spectrum. $Ru(bpy)_3^{2+}$ generates reactive oxygen species such as singlet oxygen upon absorbing photon energy (λ= 452 nm), resulting in disassembly of Aβ aggregates. Furthermore, photoexcited $Ru(bpy)_3^{2+}$ can reduce in vitro cytotoxicity of Aβ aggregates. Our study advances a new insight of ruthenium (II) complexes as therapeutic agents against AD. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Ruthenium complex | - |
dc.subject | β-amyloid | - |
dc.subject | aggregates | - |
dc.subject | disassembly | - |
dc.subject | photo-degradation | - |
dc.subject | reactive oxygen species | - |
dc.subject | 루테늄 복합체 | - |
dc.subject | 베타 아밀로이드 | - |
dc.subject | 응집체 | - |
dc.subject | 분해 | - |
dc.subject | 광분해 | - |
dc.subject | 활성 산소종 | - |
dc.title | Light-Induced Disassembly β-Amyloid Aggregates by Ruthenium Complex | - |
dc.title.alternative | 루테늄 복합체를 이용한 아밀로이드 응집체의 광화학적 분해 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :신소재공학과, | - |
dc.contributor.alternativeauthor | 손기영 | - |
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