Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression

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dc.contributor.authorKim, Hyunju yko
dc.contributor.authorJang, Minsuko
dc.contributor.authorPark, Rackhyunko
dc.contributor.authorJo, Daumko
dc.contributor.authorChoi, Inhoko
dc.contributor.authorChoe, Joonhoko
dc.contributor.authorOh, Won Keunko
dc.contributor.authorPark, Junsooko
dc.date.accessioned2018-06-19T08:30:02Z-
dc.date.available2018-06-19T08:30:02Z-
dc.date.created2018-06-18-
dc.date.created2018-06-18-
dc.date.issued2018-04-
dc.identifier.citationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.28, no.4, pp.520 - 526-
dc.identifier.issn1017-7825-
dc.identifier.urihttp://hdl.handle.net/10203/242637-
dc.description.abstractConessine, a steroidal alkaloid, is a potent histamine H3 antagonist with antimalarial activity. We recently reported that conessine treatment interferes with H2O2-induced cell death by regulating autophagy. However, the cellular signaling pathways involved in conessine treatment are not fully understood. Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1. Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, NF-kappa B-dependent transcription, and p53-dependent transcription. We also showed by quantitative RT-PCR and western blot assays that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1. Finally, we demonstrated that conessine treatment reduced dexamethasone-induced muscle atrophy using differentiated C2C12 cells. These results collectively suggest that conessine is potentially useful in the treatment of muscle atrophy.-
dc.languageEnglish-
dc.publisherKOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY-
dc.subjectSKELETAL-MUSCLE-
dc.subjectUBIQUITIN LIGASES-
dc.subjectTRANSCRIPTION FACTOR-
dc.subjectPROTEIN-KINASE-
dc.subjectTUMOR-CELLS-
dc.subjectKAPPA-B-
dc.subjectFOXO3A-
dc.subjectAPOPTOSIS-
dc.subjectGROWTH-
dc.subjectMAFBX/ATROGIN-1-
dc.titleConessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression-
dc.typeArticle-
dc.identifier.wosid000433223100003-
dc.identifier.scopusid2-s2.0-85046153543-
dc.type.rimsART-
dc.citation.volume28-
dc.citation.issue4-
dc.citation.beginningpage520-
dc.citation.endingpage526-
dc.citation.publicationnameJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.identifier.doi10.4014/jmb.1711.11009-
dc.contributor.localauthorChoe, Joonho-
dc.contributor.nonIdAuthorKim, Hyunju y-
dc.contributor.nonIdAuthorJang, Minsu-
dc.contributor.nonIdAuthorPark, Rackhyun-
dc.contributor.nonIdAuthorJo, Daum-
dc.contributor.nonIdAuthorChoi, Inho-
dc.contributor.nonIdAuthorOh, Won Keun-
dc.contributor.nonIdAuthorPark, Junsoo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorConessine-
dc.subject.keywordAuthormuscle atrophy-
dc.subject.keywordAuthorMuRF1-
dc.subject.keywordAuthoratrogin-1-
dc.subject.keywordAuthorFoxO3a-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusUBIQUITIN LIGASES-
dc.subject.keywordPlusTRANSCRIPTION FACTOR-
dc.subject.keywordPlusPROTEIN-KINASE-
dc.subject.keywordPlusTUMOR-CELLS-
dc.subject.keywordPlusKAPPA-B-
dc.subject.keywordPlusFOXO3A-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusMAFBX/ATROGIN-1-
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