DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ryunhee | ko |
dc.contributor.author | Kim, Jihye | ko |
dc.contributor.author | Chung, Changuk | ko |
dc.contributor.author | Ha, Seungmin | ko |
dc.contributor.author | Lee, Seungjoon | ko |
dc.contributor.author | Lee, Eunee | ko |
dc.contributor.author | Yoo, Ye Eun | ko |
dc.contributor.author | Kim, Woohyun | ko |
dc.contributor.author | Shin, Wangyong | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2018-05-24T02:44:23Z | - |
dc.date.available | 2018-05-24T02:44:23Z | - |
dc.date.created | 2018-05-14 | - |
dc.date.created | 2018-05-14 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE, v.38, no.17, pp.4076 - 4092 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10203/242364 | - |
dc.description.abstract | Shank2 is an excitatory postsynaptic scaffolding protein implicated in synaptic regulation and psychiatric disorders including autism spectrum disorders. Conventional Shank2-mutant (Shank2(-/-)) mice display several autistic-like behaviors, including social deficits, repetitive behaviors, hyperactivity, and anxiety-like behaviors. However, cell-type-specific contributions to these behaviors have remained largely unclear. Here, we deleted Shank2 in specific cell types and found that male mice lacking Shank2 in excitatory neurons (CaMKII-Cre;Shank2(fl/fl)) show social interaction deficits and mild social communication deficits, hyperactivity, and anxiety-like behaviors. In particular, male mice lacking Shank2 in GABAergic inhibitory neurons (Viaat-Cre;Shank2(fl/fl)) display social communication deficits, repetitive self-grooming, and mild hyperactivity. These behavioral changes were associated with distinct changes in hippocampal and striatal synaptic transmission in the two mouse lines. These results indicate that cell-type-specific deletions of Shank2 in mice lead to differential synaptic and behavioral abnormalities. | - |
dc.language | English | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.subject | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject | AUTISM SPECTRUM DISORDERS | - |
dc.subject | CEREBELLAR PURKINJE-CELLS | - |
dc.subject | BINDING-PROTEIN | - |
dc.subject | SPINY NEURONS | - |
dc.subject | NEUROPSYCHIATRIC DISORDERS | - |
dc.subject | ULTRASONIC VOCALIZATIONS | - |
dc.subject | DOPAMINERGIC MODULATION | - |
dc.subject | SCAFFOLD PROTEINS | - |
dc.subject | SUBSTRATE IRSP53 | - |
dc.title | Cell-Type-Specific Shank2 Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes | - |
dc.type | Article | - |
dc.identifier.wosid | 000431123900004 | - |
dc.identifier.scopusid | 2-s2.0-85049020028 | - |
dc.type.rims | ART | - |
dc.citation.volume | 38 | - |
dc.citation.issue | 17 | - |
dc.citation.beginningpage | 4076 | - |
dc.citation.endingpage | 4092 | - |
dc.citation.publicationname | JOURNAL OF NEUROSCIENCE | - |
dc.identifier.doi | 10.1523/JNEUROSCI.2684-17.2018 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Kim, Jihye | - |
dc.contributor.nonIdAuthor | Chung, Changuk | - |
dc.contributor.nonIdAuthor | Lee, Eunee | - |
dc.contributor.nonIdAuthor | Kim, Woohyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | autism | - |
dc.subject.keywordAuthor | cell type | - |
dc.subject.keywordAuthor | excitatory | - |
dc.subject.keywordAuthor | inhibitory | - |
dc.subject.keywordAuthor | Shank2 | - |
dc.subject.keywordAuthor | synapse | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject.keywordPlus | AUTISM SPECTRUM DISORDERS | - |
dc.subject.keywordPlus | CEREBELLAR PURKINJE-CELLS | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | SPINY NEURONS | - |
dc.subject.keywordPlus | NEUROPSYCHIATRIC DISORDERS | - |
dc.subject.keywordPlus | ULTRASONIC VOCALIZATIONS | - |
dc.subject.keywordPlus | DOPAMINERGIC MODULATION | - |
dc.subject.keywordPlus | SCAFFOLD PROTEINS | - |
dc.subject.keywordPlus | SUBSTRATE IRSP53 | - |
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