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College of Life Science and Bioengineering(생명과학기술대학)Graduate School of Medical Science & Engineering(의과학대학원)MSE-Journal Papers(저널논문)

Alterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments

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dc.contributor.authorCho, Sung-Yupko
dc.contributor.authorSung, Chang Ohkko
dc.contributor.authorChae, Jeesooko
dc.contributor.authorLee, Jieunko
dc.contributor.authorNa, Deukchaeko
dc.contributor.authorKang, Wonyoungko
dc.contributor.authorKang, Jinjooko
dc.contributor.authorMin, Seoyeonko
dc.contributor.authorLee, Ahrako
dc.contributor.authorKwak, Eunhyeko
dc.contributor.authorKim, Jooyoungko
dc.contributor.authorChoi, Boramko
dc.contributor.authorKim, Hyunsooko
dc.contributor.authorChuang, Jeffrey H.ko
dc.contributor.authorPak, Hyo-Kyungko
dc.contributor.authorPark, Chan-Sikko
dc.contributor.authorPark, Sanghuiko
dc.contributor.authorKo, Young Hyehko
dc.contributor.authorLee, Dakeunko
dc.contributor.authorRoh, Jinko
dc.contributor.authorCho, Min-Sunko
dc.contributor.authorPark, Seongyeolko
dc.contributor.authorJu, Young Seokko
dc.contributor.authorSuh, Yun-Suhkko
dc.contributor.authorKong, Seong-Hoko
dc.contributor.authorLee, Hyuk-Joonko
dc.contributor.authorKeck, Jamesko
dc.contributor.authorBanchereau, Jacquesko
dc.contributor.authorLiu, Edison T.ko
dc.contributor.authorKim, Woo-Hoko
dc.contributor.authorPark, Hansooko
dc.contributor.authorYang, Han-Kwangko
dc.contributor.authorKim, Jong-Ilko
dc.contributor.authorLee, Charlesko
dc.date.accessioned2018-05-24T02:24:08Z-
dc.date.available2018-05-24T02:24:08Z-
dc.date.created2018-05-14-
dc.date.created2018-05-14-
dc.date.issued2018-04-
dc.identifier.citationBLOOD, v.131, no.17, pp.1931 - 1941-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10203/242250-
dc.description.abstractEpstein-Barr virus (EBV)-positive diffuse large B-cell lymphomas (EBV1-DLBLs) tend to occur in immunocompromised patients, such as the elderly or those undergoing solid organ transplantation. The pathogenesis and genomic characteristics of EBV1-DLBLs are largely unknown because of the limited availability of human samples and lack of experimental animal models. We observed the development of 25 human EBV1-DLBLs during the engraftment of gastric adenocarcinomas into immunodeficient mice. An integrated genomic analysis of the human-derived EBV1-DLBLs revealed enrichment ofmutations in Rho pathway genes, including RHPN2, and Rho pathway transcriptomic activation. Targeting the Rho pathway using a Rho-associated protein kinase (ROCK) inhibitor, fasudil, markedly decreased tumorgrowth inEBV1-DLBL patient-derived xenograft (PDX) models. Thus, alterations in the Rho pathway appear to contribute to EBV-induced lymphomagenesis in immunosuppressed environments.-
dc.languageEnglish-
dc.publisherAMER SOC HEMATOLOGY-
dc.subjectB-CELL LYMPHOMA-
dc.subjectDNA-SEQUENCING DATA-
dc.subjectRNA-SEQ-
dc.subjectCANCER-
dc.subjectMUTATIONS-
dc.subjectMICE-
dc.subjectXENOGRAFTS-
dc.subjectFRAMEWORK-
dc.subjectJUNCTIONS-
dc.titleAlterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments-
dc.typeArticle-
dc.identifier.wosid000431101100010-
dc.identifier.scopusid2-s2.0-85047871272-
dc.type.rimsART-
dc.citation.volume131-
dc.citation.issue17-
dc.citation.beginningpage1931-
dc.citation.endingpage1941-
dc.citation.publicationnameBLOOD-
dc.identifier.doi10.1182/blood-2017-07-797209-
dc.contributor.localauthorJu, Young Seok-
dc.contributor.nonIdAuthorCho, Sung-Yup-
dc.contributor.nonIdAuthorSung, Chang Ohk-
dc.contributor.nonIdAuthorChae, Jeesoo-
dc.contributor.nonIdAuthorLee, Jieun-
dc.contributor.nonIdAuthorNa, Deukchae-
dc.contributor.nonIdAuthorKang, Wonyoung-
dc.contributor.nonIdAuthorKang, Jinjoo-
dc.contributor.nonIdAuthorMin, Seoyeon-
dc.contributor.nonIdAuthorLee, Ahra-
dc.contributor.nonIdAuthorKwak, Eunhye-
dc.contributor.nonIdAuthorKim, Jooyoung-
dc.contributor.nonIdAuthorChoi, Boram-
dc.contributor.nonIdAuthorKim, Hyunsoo-
dc.contributor.nonIdAuthorChuang, Jeffrey H.-
dc.contributor.nonIdAuthorPak, Hyo-Kyung-
dc.contributor.nonIdAuthorPark, Chan-Sik-
dc.contributor.nonIdAuthorPark, Sanghui-
dc.contributor.nonIdAuthorKo, Young Hyeh-
dc.contributor.nonIdAuthorLee, Dakeun-
dc.contributor.nonIdAuthorRoh, Jin-
dc.contributor.nonIdAuthorCho, Min-Sun-
dc.contributor.nonIdAuthorPark, Seongyeol-
dc.contributor.nonIdAuthorSuh, Yun-Suhk-
dc.contributor.nonIdAuthorKong, Seong-Ho-
dc.contributor.nonIdAuthorLee, Hyuk-Joon-
dc.contributor.nonIdAuthorKeck, James-
dc.contributor.nonIdAuthorBanchereau, Jacques-
dc.contributor.nonIdAuthorLiu, Edison T.-
dc.contributor.nonIdAuthorKim, Woo-Ho-
dc.contributor.nonIdAuthorPark, Hansoo-
dc.contributor.nonIdAuthorYang, Han-Kwang-
dc.contributor.nonIdAuthorKim, Jong-Il-
dc.contributor.nonIdAuthorLee, Charles-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusB-CELL LYMPHOMA-
dc.subject.keywordPlusDNA-SEQUENCING DATA-
dc.subject.keywordPlusRNA-SEQ-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusXENOGRAFTS-
dc.subject.keywordPlusFRAMEWORK-
dc.subject.keywordPlusJUNCTIONS-
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