Identification and evaluation of scaffold protein mediated type 2 diabetes mechanisms = 골격단백질 매개 제2형 당뇨 기전 발굴 및 평가

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Since scaffold proteins are identified as key regulatory modulators of cellular functions, several studies have been tried to discover specific scaffolding functions and predict novel scaffold proteins. Although scaffold proteins are thought to play important roles in disease development and treatments, comprehensive researches for understanding of disease-associated scaffold protein are lacking. In this study, we have developed the methods to prioritize diabetes-associated scaffold proteins and identify novel scaffold protein-mediated type 2 diabetes (T2D) mechanisms. We predicted novel scaffold proteins and integrated the known and predicted scaffold proteins with their partner proteins based on different criteria. We collected various resources related to type 2 diabetes and comprehensively analyzed pathways to understand the mechanisms of T2D. Diabetes-associated scaffold proteins are defined by direct and indirect association with known diabetes-related genes and their functions. With support evidences we selected the diabetes-associated functional scaffold protein modules and finally suggested the scaffold protein-mediated diabetes mechanism models. We also implemented the web-based system for browsing, searching and analyzing of diabetes-associated scaffold protein modules to study novel mechanisms or discover novel therapeutic target candidates. This versatile platform can be directly used for identification and prioritization of novel therapeutic targets and regulatory mechanisms for type 2 diabetes.
Advisors
Yi, GwanSuresearcher이관수researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 바이오및뇌공학과, 2017.8,[vii, 83 p. :]

Keywords

scaffold protein▼atype 2 diabetes▼amechanism▼aomics analysis▼adata mining; 골격단백질▼a제2형 당뇨▼a기전▼a오믹스 분석▼a데이터 마이닝

URI
http://hdl.handle.net/10203/241814
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=718963&flag=dissertation
Appears in Collection
BiS-Theses_Ph.D.(박사논문)
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