BRAZILIN STIMULATES THE GLUCOSE-TRANSPORT IN 3T3-L1 CELLS
Brazilin {7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol} was found to have hypoglycemic action and increase glucose metabolism in experimental diabetic animals. In order to investigate the mechanism of hypoglycemic action of brazilin, the effects of brazilin on glucose transport, insulin receptor autophosphorylation, and protein kinase C(PKC) activity in 3T3-L1 cells were studied. Brazilin increased basal glucose transport in 3T3-L1 fibroblasts and adipocytes. However, insulin-stimulated glucose transport was not influenced. Autophosphorylation of the partially purified insulin receptor was not affected by brazilin treatment in 3T3-L1 fibroblasts. However, brazilin decreased the PKC activity in 3T3-L1 fibroblasts and adipocytes.
- Publisher
- GEORG THIEME VERLAG KG
- Issue Date
- 1995-08
- Language
- English
- Article Type
- Article
- Keywords
INSULIN-RECEPTOR TYROSINE; PHORBOL ESTERS; PHOSPHORYLATION; KINASE; SERINE; ADIPOCYTES
- Citation
PLANTA MEDICA, v.61, no.4, pp.297 - 301
- ISSN
- 0032-0943
- Appears in Collection
- MSE-Journal Papers(저널논문)
- Files in This Item
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