DC Field | Value | Language |
---|---|---|
dc.contributor.author | Patterson, Heide Christine K. | ko |
dc.contributor.author | Kraus, Manfred | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Ploegh, Hidde | ko |
dc.contributor.author | Rajewsky, Klaus | ko |
dc.date.accessioned | 2018-03-21T02:57:24Z | - |
dc.date.available | 2018-03-21T02:57:24Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | IMMUNITY, v.25, no.1, pp.55 - 65 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240859 | - |
dc.description.abstract | In addition to the tyrosines of the Ig alpha and beta immunoreceptor tyrosine-based activation motifs (ITAMs), the evolutionarily conserved Ig alpha non-ITAM tyrosine 204 becomes phosphorylated upon antigen recognition by the B cell receptor (BCR). Here we demonstrate that splenic B cells from mice with a targeted mutation of Ig alpha Y204 exhibited an isolated defect in T cell-independent B cell activation, proliferation, and antibody response upon BCR engagement, yet normal BCR capping, antigen internalization, antigen presentation, and T cell-dependent antibody production. Mutant B cells, present in normal numbers, exhibited unimpaired BCR-induced spleen tyrosine kinase (Syk) phosphorylation but reduced B cell linker protein (BLNK) phosphorylation, calcium flux, and nuclear factor kappa B (NF kappa B), c-jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) activation. These results suggest that Ig alpha non-ITAM tyrosine 204 promotes a distinct cellular response, namely T-independent B cell proliferation and differentiation via phosphorylation of the adaptor BLNK. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | ANTIGEN RECEPTOR | - |
dc.subject | LINKER PROTEIN | - |
dc.subject | MOTIF ITAM | - |
dc.subject | KAPPA-B | - |
dc.subject | BLNK | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | MICE | - |
dc.subject | SLP-65 | - |
dc.subject | SYK | - |
dc.subject | PHOSPHORYLATION | - |
dc.title | The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Ig alpha cytoplasmic domain | - |
dc.type | Article | - |
dc.identifier.wosid | 000239713000010 | - |
dc.identifier.scopusid | 2-s2.0-33745973881 | - |
dc.type.rims | ART | - |
dc.citation.volume | 25 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 55 | - |
dc.citation.endingpage | 65 | - |
dc.citation.publicationname | IMMUNITY | - |
dc.identifier.doi | 10.1016/j.immuni.2006.04.014 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Patterson, Heide Christine K. | - |
dc.contributor.nonIdAuthor | Kraus, Manfred | - |
dc.contributor.nonIdAuthor | Ploegh, Hidde | - |
dc.contributor.nonIdAuthor | Rajewsky, Klaus | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANTIGEN RECEPTOR | - |
dc.subject.keywordPlus | LINKER PROTEIN | - |
dc.subject.keywordPlus | MOTIF ITAM | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | BLNK | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SLP-65 | - |
dc.subject.keywordPlus | SYK | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
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