DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pithadia, Amit S. | ko |
dc.contributor.author | Kochi, Akiko | ko |
dc.contributor.author | Soper, Molly T. | ko |
dc.contributor.author | Beck, Michael W. | ko |
dc.contributor.author | Liu, Yuzhong | ko |
dc.contributor.author | Lee, Sanghyun | ko |
dc.contributor.author | DeToma, Alaina S. | ko |
dc.contributor.author | Ruotolo, Brandon T. | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2018-02-21T06:24:53Z | - |
dc.date.available | 2018-02-21T06:24:53Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | INORGANIC CHEMISTRY, v.51, no.23, pp.12959 - 12967 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240308 | - |
dc.description.abstract | In Alzheimer's disease (AD), metal-associated amyloid-beta (metal-A beta) species have been suggested to be involved in neurotoxicity; however, their role in disease development is still unclear. To elucidate this aspect, chemical reagents have been developed as valuable tools for targeting metal-A beta species, modulating the interaction between the metal and A beta, and subsequently altering metal-A beta reactivity. Herein, we report the design, preparation, characterization, and reactivity of two diphenylpropynone derivatives (DPP1 and DPP2) composed of structural moieties for metal chelation and A beta interaction (bifunctionality). The interactions of these compounds with metal ions and A beta species were confirmed by UV-vis, NMR, mass spectrometry, and docking studies. The effects of these bifunctional molecules on the control of in vitro metal-free and metal-induced A beta aggregation were investigated and monitored by gel electrophoresis and transmission electron microscopy (TEM). Both DPP1 and DPP2 showed reactivity toward metal-A beta species over metal-free A beta species to different extents. In particular, DPP2, which contains a dimethylamino group, exhibited greater reactivity with metal-A beta species than DPP1, suggesting a structure-reactivity relationship. Overall, our studies present a new bifunctional scaffold that could be utilized to develop chemical reagents for investigating metal-A beta species in AD. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-beta Species | - |
dc.type | Article | - |
dc.identifier.wosid | 000311772600040 | - |
dc.identifier.scopusid | 2-s2.0-84870541207 | - |
dc.type.rims | ART | - |
dc.citation.volume | 51 | - |
dc.citation.issue | 23 | - |
dc.citation.beginningpage | 12959 | - |
dc.citation.endingpage | 12967 | - |
dc.citation.publicationname | INORGANIC CHEMISTRY | - |
dc.identifier.doi | 10.1021/ic302084g | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Pithadia, Amit S. | - |
dc.contributor.nonIdAuthor | Kochi, Akiko | - |
dc.contributor.nonIdAuthor | Soper, Molly T. | - |
dc.contributor.nonIdAuthor | Beck, Michael W. | - |
dc.contributor.nonIdAuthor | Liu, Yuzhong | - |
dc.contributor.nonIdAuthor | Lee, Sanghyun | - |
dc.contributor.nonIdAuthor | DeToma, Alaina S. | - |
dc.contributor.nonIdAuthor | Ruotolo, Brandon T. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISEASES | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | ZINC | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | PROGRAM | - |
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