DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyuck Jin | ko |
dc.contributor.author | Kerr, Richard A. | ko |
dc.contributor.author | Korshavn, Kyle J. | ko |
dc.contributor.author | Lee, Jeeyeon | ko |
dc.contributor.author | Kang, Juhye | ko |
dc.contributor.author | Ramamoorthy, Ayyalusamy | ko |
dc.contributor.author | Ruotolo, Brandon T. | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2018-02-21T06:06:15Z | - |
dc.date.available | 2018-02-21T06:06:15Z | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.created | 2018-02-08 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | INORGANIC CHEMISTRY FRONTIERS, v.3, no.3, pp.381 - 392 | - |
dc.identifier.issn | 2052-1553 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240276 | - |
dc.description.abstract | Amyloid-beta (A beta) and metal ions are suggested to be involved in the pathogenesis of Alzheimer's disease (AD). Cu(II) and Zn(II) can interact with A beta and facilitate peptide aggregation producing toxic oligomeric peptide species. Additionally, redox-active metal-bound A beta is shown to generate reactive oxygen species (ROS). Although the interaction of metal ions with A beta and the reactivity of metal-associated A beta (metal-A beta) are indicated, the relationship between metal-A beta and AD etiology is still unclear. Some naturally occurring flavonoids capable of redirecting metal-A beta peptides into nontoxic, off-pathway A beta aggregates have been presented as valuable tools for elucidating the role of metal-A beta in AD. The structural moieties of the flavonoids responsible for their reactivity toward metal-A beta are not identified, however. To determine a structure-interaction-reactivity relationship between flavonoids and metal-free A beta or metal-A beta, four flavonoids (morin, quercetin, galangin, and luteolin) were rationally selected based on structural variations (i.e., number and position of hydroxyl groups). These four flavonoids could noticeably modulate metal-A beta aggregation over metal-free analogue to different extents. Moreover, nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) studies reveal that the direct interactions of the flavonoids with metal-free and/or metal-bound A beta are distinct. Overall, our studies demonstrate that alternation of the hydroxyl groups on the B and C rings of flavonoids (structure) could differentiate their metal/metal-free A beta/metal-A beta interactions (interaction) and subsequently direct their effects on metal-free A beta and metal-A beta aggregation in vitro and A beta-/metal-A beta-triggered toxicity in living cells (reactivity), suggesting a structure-interaction-reactivity relationship. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-beta aggregation | - |
dc.type | Article | - |
dc.identifier.wosid | 000372250200007 | - |
dc.identifier.scopusid | 2-s2.0-84960441558 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 381 | - |
dc.citation.endingpage | 392 | - |
dc.citation.publicationname | INORGANIC CHEMISTRY FRONTIERS | - |
dc.identifier.doi | 10.1039/c5qi00219b | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Lee, Hyuck Jin | - |
dc.contributor.nonIdAuthor | Kerr, Richard A. | - |
dc.contributor.nonIdAuthor | Korshavn, Kyle J. | - |
dc.contributor.nonIdAuthor | Lee, Jeeyeon | - |
dc.contributor.nonIdAuthor | Kang, Juhye | - |
dc.contributor.nonIdAuthor | Ramamoorthy, Ayyalusamy | - |
dc.contributor.nonIdAuthor | Ruotolo, Brandon T. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MOBILITY-MASS SPECTROMETRY | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | SMALL MOLECULES | - |
dc.subject.keywordPlus | FIBRIL FORMATION | - |
dc.subject.keywordPlus | REACTIVITY | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | BINDING | - |
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