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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

Molecular shielding of porcine islets by tissue-adhesive chitosan-catechol for enhancement of in-vitro stability

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dc.contributor.authorJeong, Jee-Heonko
dc.contributor.authorWoo, Yoon-Jooko
dc.contributor.authorLee, Mihyunko
dc.contributor.authorHaque, Muhammad R.ko
dc.contributor.authorAhn, Cheol-Heeko
dc.contributor.authorLee, Haeshinko
dc.contributor.authorByun, Youngroko
dc.date.accessioned2018-02-21T05:53:38Z-
dc.date.available2018-02-21T05:53:38Z-
dc.date.created2018-02-05-
dc.date.created2018-02-05-
dc.date.issued2018-01-
dc.identifier.citationJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.57, no.25, pp.330 - 338-
dc.identifier.issn1226-086X-
dc.identifier.urihttp://hdl.handle.net/10203/240157-
dc.description.abstractPorcine islets are an alternative cell source for cell replacement therapy in diabetes. However, porcine islets are very fragile, and isolated islets are easily damaged during culture. Therefore, the purpose of this study was to incorporate a tissue-adhesive chitosan derivative on the surface of porcine islets to prevent the dissociation of porcine islet clusters into single cells. Chitosan-catechol was evenly covered on the surface of islets without any toxicity. In addition, the tissue-adhesive chitosan catechol was effective in preventing cell dissociation. Therefore, tissue adhesive chitosan-catechol conjugation onto the porcine islet surface is a promising technique to stabilize islets after isolation. (c) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE INC-
dc.subjectPANCREATIC-ISLETS-
dc.subjectEXTRACELLULAR-MATRIX-
dc.subjectSURFACE MODIFICATION-
dc.subjectNONHUMAN-PRIMATES-
dc.subjectTRANSPLANTATION-
dc.subjectXENOTRANSPLANTATION-
dc.subjectRAT-
dc.subjectSECRETION-
dc.subjectHYDROGELS-
dc.subjectSURVIVAL-
dc.titleMolecular shielding of porcine islets by tissue-adhesive chitosan-catechol for enhancement of in-vitro stability-
dc.typeArticle-
dc.identifier.wosid000422811600039-
dc.identifier.scopusid2-s2.0-85028860281-
dc.type.rimsART-
dc.citation.volume57-
dc.citation.issue25-
dc.citation.beginningpage330-
dc.citation.endingpage338-
dc.citation.publicationnameJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY-
dc.identifier.doi10.1016/j.jiec.2017.08.040-
dc.contributor.localauthorLee, Haeshin-
dc.contributor.nonIdAuthorJeong, Jee-Heon-
dc.contributor.nonIdAuthorWoo, Yoon-Joo-
dc.contributor.nonIdAuthorHaque, Muhammad R.-
dc.contributor.nonIdAuthorAhn, Cheol-Hee-
dc.contributor.nonIdAuthorByun, Youngro-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorPorcine islets-
dc.subject.keywordAuthorChitosan-catechol-
dc.subject.keywordAuthorIslet stability-
dc.subject.keywordAuthorSurface modification-
dc.subject.keywordAuthorCarbohydrate-
dc.subject.keywordPlusPANCREATIC-ISLETS-
dc.subject.keywordPlusEXTRACELLULAR-MATRIX-
dc.subject.keywordPlusSURFACE MODIFICATION-
dc.subject.keywordPlusNONHUMAN-PRIMATES-
dc.subject.keywordPlusTRANSPLANTATION-
dc.subject.keywordPlusXENOTRANSPLANTATION-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusSECRETION-
dc.subject.keywordPlusHYDROGELS-
dc.subject.keywordPlusSURVIVAL-
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CH-Journal Papers(저널논문)
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