DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Joon Ho | ko |
dc.contributor.author | Roh, Eun | ko |
dc.contributor.author | Oh, Tae Jung | ko |
dc.contributor.author | Kim, Kyoung Min | ko |
dc.contributor.author | Moon, Jae Hoon | ko |
dc.contributor.author | Lim, Soo | ko |
dc.contributor.author | Jang, Hak Chul | ko |
dc.contributor.author | Choi, Sung Hee | ko |
dc.date.accessioned | 2018-02-21T05:32:36Z | - |
dc.date.available | 2018-02-21T05:32:36Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | DIABETOLOGY & METABOLIC SYNDROME, v.9 | - |
dc.identifier.issn | 1758-5996 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240075 | - |
dc.description.abstract | Background: We assessed the impact of a family history of diabetes on type 2 diabetes, metabolic syndrome, and behavioral traits in young Korean adults. Methods: Subjects aged 25-44 years were included, and the presence of a family history of diabetes was obtained by a self-reported questionnaire (the Korea National Health and Nutrition Survey 2010). We compared the prevalence of type 2 diabetes and metabolic syndrome, and other metabolic parameters, including blood pressure and lipid profile. Results: Of 2059 participants, those with a family history of diabetes involving first-degree relatives (n = 489, 23.7%) had a significantly higher prevalence of impaired fasting glucose (14.3 vs. 11.7%) and type 2 diabetes (6.7 vs. 1.8%), compared to those without a family history (P < 0.001). The prevalence of metabolic syndrome (21.3 vs. 12.1%, P < 0.001) and its components (except for high-density lipoprotein cholesterol) were greater in subjects with a family history of diabetes. Among subjects exhibiting normal glucose tolerance (n = 1704), those with a family history of diabetes had higher fasting glucose (89.0 vs. 87.8 mg/dL, P < 0.001) and triglyceride (100.5 vs. 89.0 mg/dL, P < 0.001), and lower beta cell function by the homeostasis model assessment (HOMA-beta; 134.2 vs. 137.5, P = 0.020). The obesity indices (body mass index, waist circumference, and triglyceride) were significantly correlated with those of both parents (P < 0.01 for all variables). Risk-reducing behavior, including regular exercise (18.2 vs. 19.7%, P = 0.469) and calorie intake (2174.8 vs. 2149.1 kcal/day, P = 0.636), did not markedly differ according to a family history of diabetes. Conclusions: Young adults with a family history of diabetes had an increased risk of type 2 diabetes and metabolic syndrome, even though they currently exhibited a normal glycemic profile. Proactive lifestyle consultation is requested especially among healthy young population with a family history of diabetes. | - |
dc.language | English | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | INSULIN SENSITIVITY | - |
dc.subject | PREVALENCE | - |
dc.subject | POPULATION | - |
dc.subject | ACCURACY | - |
dc.subject | MELLITUS | - |
dc.subject | GLUCOSE | - |
dc.subject | PLASMA | - |
dc.subject | TRENDS | - |
dc.title | Increased risk of metabolic disorders in healthy young adults with family history of diabetes: from the Korea National Health and Nutrition Survey | - |
dc.type | Article | - |
dc.identifier.wosid | 000395827300001 | - |
dc.identifier.scopusid | 2-s2.0-85014259099 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.publicationname | DIABETOLOGY & METABOLIC SYNDROME | - |
dc.identifier.doi | 10.1186/s13098-017-0210-8 | - |
dc.contributor.nonIdAuthor | Roh, Eun | - |
dc.contributor.nonIdAuthor | Oh, Tae Jung | - |
dc.contributor.nonIdAuthor | Kim, Kyoung Min | - |
dc.contributor.nonIdAuthor | Moon, Jae Hoon | - |
dc.contributor.nonIdAuthor | Lim, Soo | - |
dc.contributor.nonIdAuthor | Jang, Hak Chul | - |
dc.contributor.nonIdAuthor | Choi, Sung Hee | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Family history | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | type 2 | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | TRENDS | - |
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