DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Hee | ko |
dc.date.accessioned | 2018-02-21T04:25:20Z | - |
dc.date.available | 2018-02-21T04:25:20Z | - |
dc.date.created | 2017-12-20 | - |
dc.date.issued | 2017-05-16 | - |
dc.identifier.citation | GBB meeting | - |
dc.identifier.uri | http://hdl.handle.net/10203/239748 | - |
dc.description.abstract | When conflicts occur during integration of visual and auditory information, one modality often dominates the other, but the underlying neural circuit mechanism remains unclear. Using auditory-visual discrimination tasks for head-fixed mice, we found that audition dominates vision in a process mediated by interaction between inputs from the primary visual (VC) and auditory (AC) cortices in the posterior parietal cortex (PTLp). Co-activation of the VC and AC suppresses VC-induced PTLp responses, leaving AC-induced responses. Furthermore, parvalbumin-positive (PV+) interneurons in the PTLp mainly receive AC inputs, and muscimol inactivation of the PTLp or optogenetic inhibition of its PV+ neurons abolishes auditory dominance in the resolution of cross-modal sensory conflicts without affecting either sensory perception. Conversely, optogenetic activation of PV+ neurons in the PTLp enhances the auditory dominance. Thus, our results demonstrate that AC input-specific feedforward inhibition of VC inputs in the PTLp is responsible for the auditory dominance during cross-modal integration. | - |
dc.language | English | - |
dc.publisher | IBANGS | - |
dc.title | A neural circuit for auditory dominance over visual perception | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | GBB meeting | - |
dc.identifier.conferencecountry | SP | - |
dc.identifier.conferencelocation | Madrid | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
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