DC Field | Value | Language |
---|---|---|
dc.contributor.author | In, Suna | ko |
dc.contributor.author | Lee, Yejin | ko |
dc.contributor.author | Lee, Jinhwan | ko |
dc.contributor.author | Kim, Jaehoon | ko |
dc.date.accessioned | 2018-01-22T02:30:48Z | - |
dc.date.available | 2018-01-22T02:30:48Z | - |
dc.date.created | 2017-12-21 | - |
dc.date.issued | 2017-09-13 | - |
dc.identifier.citation | 2017 International Conference of the Korean Society for Molecular and Cellular Biology | - |
dc.identifier.uri | http://hdl.handle.net/10203/237407 | - |
dc.description.abstract | Histone H2B ubiquitylation has been implicated in transcriptional regulation. In humans, RING-finger domain type E3 ubiquitin ligase RNF20/40 catalyzes monoubiquitylation of histone H2B and participates in various biological processes. However, it is uncertain that all these RNF20/40-related cellular events are only mediated by H2B ubiquitylation. Several researches suggest that some of these events might be due to additional substrates of RNF20/40. In order to identify unknown non-histone substrates of RNF20/40, we tried immunoprecipitation using FLAG-RNF20 cell line to screen RNF20/40-interacting proteins. Coimmunoprecipitated proteins were identified by mass spectrometry analysis. We found that isoform 2 of elongation factor 1-delta, eEF1deltaL, directly interacts with RNF20/40 and is ubiquitylated by RNF20/40. We show that function of eEF1deltaL as a heat shock response transcription factor is facilitated by RNF20/40. | - |
dc.language | English | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.title | Identification and characterization of eEF1BδL as a substrate of RNF20/40 | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | 2017 International Conference of the Korean Society for Molecular and Cellular Biology | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | COEX, Seoul | - |
dc.contributor.localauthor | Kim, Jaehoon | - |
dc.contributor.nonIdAuthor | Lee, Yejin | - |
dc.contributor.nonIdAuthor | Lee, Jinhwan | - |
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