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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

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dc.contributor.authorKim, Daesooko
dc.contributor.authorJun, Ki Sunko
dc.contributor.authorLee, Seong Beomko
dc.contributor.authorKang, Nae-Gyuko
dc.contributor.authorMin, Do Sikko
dc.contributor.authorKim, Young-Hoonko
dc.contributor.authorRyu, Sung Hoko
dc.contributor.authorSuh, Pann-Ghillko
dc.contributor.authorShin, Hee-Supko
dc.date.accessioned2011-04-21T05:10:34Z-
dc.date.available2011-04-21T05:10:34Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1997-09-
dc.identifier.citationNATURE, v.389, no.6648, pp.290 - 293-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10203/23310-
dc.description.abstractA variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins'. There are four isoenzymes of PLC-beta, beta 1-beta 4, but their functions in vivo are not known. Here we investigate the role of PLC-beta 1 and PLC-beta 4 in the brain by generating-null mutations in mice: we found that PLC beta 1(-/-) mice developed epilepsy and PLC beta 4(-/-) mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta 1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling pre-dominantly to the muscarinic acetylcholine receptor, whereas PLC-beta 4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain.-
dc.description.sponsorshipThis Letter is dedicated to the late Dr. Hogil Kim, the former president of POSTECH, who made this work possible. H.-S.S. thanks E. Park for comments on the manuscript and E. B. Lee and B. J. Pak for their early contribution to this work. We thank S. G. Rhee for PLC-b1 cDNA, Y. Namkung for ES cell culture, I. S. Kim, I. B. Kim, H. D. Noh, C. T. Choi and I. S. Lee for help with histology, and H. Y. Lee for video processing. This work was supported in part by a genetic engineering grant from the Ministry of Education and a medical science grant fromthe Ministry of Health andWelfare of Korea, and by grants from the Basic Science Research Institute and from the School of Environmental Engineering, POSTECH.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherMACMILLAN MAGAZINES LTD-
dc.subjectPHOSPHOINOSITIDE HYDROLYSIS-
dc.subjectSIGNAL-TRANSDUCTION-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectMESSENGER-RNAS-
dc.subjectRAT-BRAIN-
dc.subjectEPILEPSY-
dc.subjectSEIZURES-
dc.subjectMICE-
dc.subjectLOCALIZATION-
dc.subjectINTERNEURONS-
dc.titlePhospholipase C isozymes selectively couple to specific neurotransmitter receptors-
dc.typeArticle-
dc.identifier.wosidA1997XW77200049-
dc.identifier.scopusid2-s2.0-1842373861-
dc.type.rimsART-
dc.citation.volume389-
dc.citation.issue6648-
dc.citation.beginningpage290-
dc.citation.endingpage293-
dc.citation.publicationnameNATURE-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.nonIdAuthorJun, Ki Sun-
dc.contributor.nonIdAuthorLee, Seong Beom-
dc.contributor.nonIdAuthorKang, Nae-Gyu-
dc.contributor.nonIdAuthorMin, Do Sik-
dc.contributor.nonIdAuthorKim, Young-Hoon-
dc.contributor.nonIdAuthorRyu, Sung Ho-
dc.contributor.nonIdAuthorSuh, Pann-Ghill-
dc.contributor.nonIdAuthorShin, Hee-Sup-
dc.type.journalArticleArticle-
dc.subject.keywordPlusPHOSPHOINOSITIDE HYDROLYSIS-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusMESSENGER-RNAS-
dc.subject.keywordPlusRAT-BRAIN-
dc.subject.keywordPlusEPILEPSY-
dc.subject.keywordPlusSEIZURES-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusINTERNEURONS-
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