DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Song, I | ko |
dc.contributor.author | Keum, S | ko |
dc.contributor.author | Lee, T | ko |
dc.contributor.author | Jeong, MJ | ko |
dc.contributor.author | Kim, SS | ko |
dc.contributor.author | McEnery, MW | ko |
dc.contributor.author | Shin, HS | ko |
dc.date.accessioned | 2011-03-21T05:12:09Z | - |
dc.date.available | 2011-03-21T05:12:09Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-07 | - |
dc.identifier.citation | NEURON, v.31, no.1, pp.35 - 45 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/22826 | - |
dc.description.abstract | T-type Ca2+ currents have been proposed to be involved in the genesis of spike-and-wave discharges, a sign of absence seizures, but direct evidence in vivo to support this hypothesis has been lacking. To address this question, we generated a null mutation of the alpha (1G) subunit of T-type Ca2+ channels. The thalamocortical relay neurons of the alpha (1G)-deficient mice lacked the burst mode firing of action potentials, whereas they showed the normal pattern of tonic mode firing. The alpha (1G)-deficient thalamus was specifically resistant to the generation of spike-and-wave discharges in response to GABA(B) receptor activation. Thus, the modulation of the intrinsic firing pattern mediated by alpha (1G) T-type Ca2+ channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway. | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | CELL PRESS | - |
dc.subject | LATERAL GENICULATE-NUCLEUS | - |
dc.subject | SYNCHRONOUS EPILEPTIC DISCHARGES | - |
dc.subject | GENERALIZED PENICILLIN EPILEPSY | - |
dc.subject | THALAMIC NEURONS | - |
dc.subject | CALCIUM-CHANNEL | - |
dc.subject | GABA(B) RECEPTORS | - |
dc.subject | WAVE DISCHARGES | - |
dc.subject | RESPONSE-MODES | - |
dc.subject | LOW-THRESHOLD | - |
dc.subject | RAT | - |
dc.title | Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca2+ channels | - |
dc.type | Article | - |
dc.identifier.wosid | 000170101100009 | - |
dc.type.rims | ART | - |
dc.citation.volume | 31 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 35 | - |
dc.citation.endingpage | 45 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/S0896-6273(01)00343-9 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.nonIdAuthor | Song, I | - |
dc.contributor.nonIdAuthor | Keum, S | - |
dc.contributor.nonIdAuthor | Lee, T | - |
dc.contributor.nonIdAuthor | Jeong, MJ | - |
dc.contributor.nonIdAuthor | Kim, SS | - |
dc.contributor.nonIdAuthor | McEnery, MW | - |
dc.contributor.nonIdAuthor | Shin, HS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LATERAL GENICULATE-NUCLEUS | - |
dc.subject.keywordPlus | SYNCHRONOUS EPILEPTIC DISCHARGES | - |
dc.subject.keywordPlus | GENERALIZED PENICILLIN EPILEPSY | - |
dc.subject.keywordPlus | THALAMIC NEURONS | - |
dc.subject.keywordPlus | CALCIUM-CHANNEL | - |
dc.subject.keywordPlus | GABA(B) RECEPTORS | - |
dc.subject.keywordPlus | WAVE DISCHARGES | - |
dc.subject.keywordPlus | RESPONSE-MODES | - |
dc.subject.keywordPlus | LOW-THRESHOLD | - |
dc.subject.keywordPlus | RAT | - |
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