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College of Engineering(공과대학)Dept. of Chemical and Biomolecular Engineering(생명화학공학과)CBE-Journal Papers(저널논문)

Metabolic flux analysis and metabolic engineering of microorganisms

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dc.contributor.authorKim, Hyun Ukko
dc.contributor.authorKim, Tae Yongko
dc.contributor.authorLee, SangYupko
dc.date.accessioned2011-03-17T08:23:10Z-
dc.date.available2011-03-17T08:23:10Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2008-02-
dc.identifier.citationMOLECULAR BIOSYSTEMS, v.4, no.2, pp.113 - 120-
dc.identifier.issn1742-206X-
dc.identifier.urihttp://hdl.handle.net/10203/22756-
dc.description.abstractRecent advances in metabolic flux analysis including genome- scale constraints-based flux analysis and its applications in metabolic engineering are reviewed. Various computational aspects of constraints-based flux analysis including genome- scale stoichiometric models, additional constraints used for the improved accuracy, and several algorithms for identifying the target genes to be manipulated are described. Also, some of the successful applications of metabolic flux analysis in metabolic engineering are reviewed. Finally, we discuss the limitations that need to be overcome to make the results of genome- scale flux analysis more realistically represent the real cell metabolism.-
dc.description.sponsorshipThis work was supported by the Korean Systems Biology Program from the Ministry of Science and Technology through the Korea Science and Engineering Foundation (No. M10309020000- 03B5002-00000). Further support by LG Chem Chair Professorship is appreciated.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherROYAL SOC CHEMISTRY-
dc.titleMetabolic flux analysis and metabolic engineering of microorganisms-
dc.typeArticle-
dc.identifier.wosid000252553500002-
dc.identifier.scopusid2-s2.0-38349151554-
dc.type.rimsART-
dc.citation.volume4-
dc.citation.issue2-
dc.citation.beginningpage113-
dc.citation.endingpage120-
dc.citation.publicationnameMOLECULAR BIOSYSTEMS-
dc.identifier.doi10.1039/b712395g-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorKim, Hyun Uk-
dc.contributor.localauthorLee, SangYup-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusGENOME-SCALE RECONSTRUCTION-
dc.subject.keywordPlusHAEMOPHILUS-INFLUENZAE RD-
dc.subject.keywordPlusGENE KNOCKOUT SIMULATION-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusPATHWAY ANALYSIS-
dc.subject.keywordPlusSACCHAROMYCES-CEREVISIAE-
dc.subject.keywordPlusHIGH-THROUGHPUT-
dc.subject.keywordPlusMANNHEIMIA-SUCCINICIPRODUCENS-
dc.subject.keywordPlusBIOCHEMICAL NETWORKS-
dc.subject.keywordPlusSTRAIN IMPROVEMENT-
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