Highly uniform and dense, hexagonal noble metal nanoparticle arrays were achieved on large-area
transparent glass substrates via scalable, parallel processing of block copolymer lithography. Exploring
their localized surface plasmon resonance (LSPR) characteristics revealed that the Ag nanoparticle
array displayed a UV-vis absorbance spectrum sufficiently narrow and intense for biosensing
application. A highly-sensitive, label-free detection of prostate cancer specific antibody (anti-PSA) with
sub-ng ml1 level detection limit (0.11 ng ml1) has been accomplished with the plasmonic
nanostructure. Our approach offers a valuable route to a low-cost, manufacture-scale production of
plasmonic nanostructures, potentially useful for various photonic and optoelectronic devices.