DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dong Yun | ko |
dc.contributor.author | Kim, Jinyong | ko |
dc.contributor.author | Lee, Yonghyun | ko |
dc.contributor.author | Lee, Soyoung | ko |
dc.contributor.author | Miao, Wenjun | ko |
dc.contributor.author | Kim, Hyeon Sik | ko |
dc.contributor.author | Min, Jung-Joon | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2017-11-21T04:06:54Z | - |
dc.date.available | 2017-11-21T04:06:54Z | - |
dc.date.created | 2017-11-20 | - |
dc.date.created | 2017-11-20 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.56, no.44, pp.13684 - 13688 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/227208 | - |
dc.description.abstract | Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150-nm-size NPs. Upon near-IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer-bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | IN-VIVO | - |
dc.subject | POLYMERIC MICELLES | - |
dc.subject | TUMOR | - |
dc.subject | NANOMEDICINE | - |
dc.subject | NANOCRYSTALS | - |
dc.subject | PERSPECTIVE | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | NANOSHEETS | - |
dc.subject | COMPLEXES | - |
dc.subject | CISPLATIN | - |
dc.title | Black Pigment Gallstone Inspired Platinum-Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers | - |
dc.type | Article | - |
dc.identifier.wosid | 000413314800023 | - |
dc.identifier.scopusid | 2-s2.0-85030178026 | - |
dc.type.rims | ART | - |
dc.citation.volume | 56 | - |
dc.citation.issue | 44 | - |
dc.citation.beginningpage | 13684 | - |
dc.citation.endingpage | 13688 | - |
dc.citation.publicationname | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.identifier.doi | 10.1002/anie.201707137 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Lee, Yonghyun | - |
dc.contributor.nonIdAuthor | Lee, Soyoung | - |
dc.contributor.nonIdAuthor | Miao, Wenjun | - |
dc.contributor.nonIdAuthor | Kim, Hyeon Sik | - |
dc.contributor.nonIdAuthor | Min, Jung-Joon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | anticancer therapy | - |
dc.subject.keywordAuthor | bilirubin nanoparticles | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | photoacoustic imaging | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | NANOMEDICINE | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | PERSPECTIVE | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | CISPLATIN | - |
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