DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, DaeYong | ko |
dc.contributor.author | Lee, Soo-Hwan | ko |
dc.contributor.author | Na, Youjin | ko |
dc.contributor.author | Noh, Ilkoo | ko |
dc.contributor.author | Ha, JongHoon | ko |
dc.contributor.author | Yoo, Jisang | ko |
dc.contributor.author | Bang, Hyun Bae | ko |
dc.contributor.author | Park, Jong Hyun | ko |
dc.contributor.author | Jeong, Ki Jun | ko |
dc.contributor.author | Yun, Chae-Ok | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.date.accessioned | 2017-11-08T02:21:15Z | - |
dc.date.available | 2017-11-08T02:21:15Z | - |
dc.date.created | 2017-10-23 | - |
dc.date.created | 2017-10-23 | - |
dc.date.created | 2017-10-23 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.264, pp.24 - 33 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226703 | - |
dc.description.abstract | Artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. In this study, pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. This work presents a promising peptide therapeutic system for cancer therapy. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000412177500003 | - |
dc.identifier.scopusid | 2-s2.0-85027857846 | - |
dc.type.rims | ART | - |
dc.citation.volume | 264 | - |
dc.citation.beginningpage | 24 | - |
dc.citation.endingpage | 33 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/j.jconrel.2017.08.001 | - |
dc.contributor.localauthor | Jeong, Ki Jun | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Lee, Soo-Hwan | - |
dc.contributor.nonIdAuthor | Na, Youjin | - |
dc.contributor.nonIdAuthor | Ha, JongHoon | - |
dc.contributor.nonIdAuthor | Yun, Chae-Ok | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | pH-activated helical formation | - |
dc.subject.keywordAuthor | Mitochondrial membrane destabilization | - |
dc.subject.keywordAuthor | Pro-apoptotic activity | - |
dc.subject.keywordAuthor | Cancer targeting and therapy | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | PENETRATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.