DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, Wongu | ko |
dc.contributor.author | Ko, Eun Hyea | ko |
dc.contributor.author | Kim, Mihee | ko |
dc.contributor.author | Park, Matthew Y | ko |
dc.contributor.author | Hong, Daewha | ko |
dc.contributor.author | Seisenbaeva, Gulaim A. | ko |
dc.contributor.author | Kessler, Vadim G. | ko |
dc.contributor.author | Choi, Insung S. | ko |
dc.date.accessioned | 2017-09-25T05:12:38Z | - |
dc.date.available | 2017-09-25T05:12:38Z | - |
dc.date.created | 2017-09-11 | - |
dc.date.created | 2017-09-11 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.56, no.36, pp.10702 - 10706 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226006 | - |
dc.description.abstract | Lymphocytes, such as T cells and natural killer (NK) cells, have therapeutic promise in adoptive cell transfer (ACT) therapy, where the cells are activated and expanded in vitro and then infused into a patient. However, the in vitro preservation of labile lymphocytes during transfer, manipulation, and storage has been one of the bottlenecks in the development and commercialization of therapeutic lymphocytes. Herein, we suggest a cell-in-shell (or artificial spore) strategy to enhance the cell viability in the practical settings, while maintaining biological activities for therapeutic efficacy. A durable titanium oxide (TiO2) shell is formed on individual Jurkat T cells, and the CD3 and other antigens on cell surfaces remain accessible to the antibodies. Interleukin-2 (IL-2) secretion is also not hampered by the shell formation. This work suggests a chemical toolbox for effectively preserving lymphocytes in vitro and developing the lymphocyte-based cancer immunotherapy. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | TITANIUM-DIOXIDE | - |
dc.subject | LIVING CELLS | - |
dc.subject | CHLORELLA CELLS | - |
dc.subject | SURFACE | - |
dc.subject | CANCER | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | ACTIVATION | - |
dc.subject | STABILITY | - |
dc.subject | NANOSHELL | - |
dc.title | Cytoprotective Encapsulation of Individual Jurkat T Cells within Durable TiO2 Shells for T-Cell Therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000408267000011 | - |
dc.identifier.scopusid | 2-s2.0-85021182637 | - |
dc.type.rims | ART | - |
dc.citation.volume | 56 | - |
dc.citation.issue | 36 | - |
dc.citation.beginningpage | 10702 | - |
dc.citation.endingpage | 10706 | - |
dc.citation.publicationname | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.identifier.doi | 10.1002/anie.201703886 | - |
dc.contributor.localauthor | Choi, Insung S. | - |
dc.contributor.nonIdAuthor | Hong, Daewha | - |
dc.contributor.nonIdAuthor | Seisenbaeva, Gulaim A. | - |
dc.contributor.nonIdAuthor | Kessler, Vadim G. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | artificial spores | - |
dc.subject.keywordAuthor | cytoprotection | - |
dc.subject.keywordAuthor | immunology | - |
dc.subject.keywordAuthor | mineralization | - |
dc.subject.keywordAuthor | titanates | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | TITANIUM-DIOXIDE | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | CHLORELLA CELLS | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | NANOSHELL | - |
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