DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Geon | ko |
dc.contributor.author | Kim, Tackhoon | ko |
dc.contributor.author | Chung, Chaeuk | ko |
dc.contributor.author | Hwang, Deog-Su | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2017-09-08T05:22:26Z | - |
dc.date.available | 2017-09-08T05:22:26Z | - |
dc.date.created | 2017-08-28 | - |
dc.date.created | 2017-08-28 | - |
dc.date.created | 2017-08-28 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.490, no.3, pp.650 - 656 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/225663 | - |
dc.description.abstract | YAP (Yes-associated protein) and TAZ (transcription activator with PDZ binding motif) are important in tissue regeneration and cancer development, highlighting the importance of discovering partners that regulate their oncogenicity. SGK1 (serum/glucocorticoid regulated kinase 1), initially identified as a homolog of Akt in phosphoinositide 3-kinase signaling, acts as a serine/threonine protein kinase in multiple oncogenic pathways. However, possible links between SGK1 and Hippo-YAP/TAZ signaling remain unexplored. Here, we reveal that SGK1 is a potential positive feedback regulator of YAP and TAZ, showing that the TEAD-YANTAZ complex directly activates SGK1 transcription by binding to the distal enhancer of SGK1, and SGK1, in turn, stabilizes YAP/TAZ. Moreover, we demonstrate that expression of YAP/TAZ target genes is positively regulated by SGKl. Mechanistically, SGK1 inhibits ubiquitin-mediated degradation of TAZ by inhibiting GSK3 beta activity. These findings expand our understanding of YAP/TAZ regulation to include the novel downstream target of YAP, SGK1. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | The novel YAP target gene, SGK1, upregulates TAZ activity by blocking GSK3 beta-mediated TAZ destabilization | - |
dc.type | Article | - |
dc.identifier.wosid | 000406820600010 | - |
dc.identifier.scopusid | 2-s2.0-85021165438 | - |
dc.type.rims | ART | - |
dc.citation.volume | 490 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 650 | - |
dc.citation.endingpage | 656 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.06.092 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Yoo, Geon | - |
dc.contributor.nonIdAuthor | Chung, Chaeuk | - |
dc.contributor.nonIdAuthor | Hwang, Deog-Su | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | SGK1 | - |
dc.subject.keywordAuthor | YAP | - |
dc.subject.keywordAuthor | TAZ | - |
dc.subject.keywordAuthor | Hippo pathway | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | SIZE-CONTROL | - |
dc.subject.keywordPlus | KINASE SGK | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | DEGRADATION | - |
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