DC Field | Value | Language |
---|---|---|
dc.contributor.author | Snow, CD | ko |
dc.contributor.author | Sorin, EJ | ko |
dc.contributor.author | Rhee, Young Min | ko |
dc.contributor.author | Pande, VS | ko |
dc.date.accessioned | 2017-08-16T08:55:57Z | - |
dc.date.available | 2017-08-16T08:55:57Z | - |
dc.date.created | 2017-08-07 | - |
dc.date.created | 2017-08-07 | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, v.34, pp.43 - 69 | - |
dc.identifier.issn | 1056-8700 | - |
dc.identifier.uri | http://hdl.handle.net/10203/225419 | - |
dc.description.abstract | Simulation of protein folding has come a long way in five years. Notably, new quantitative comparisons with experiments for small, rapidly folding proteins have become possible. As the only way to validate simulation methodology, this achievement marks a significant advance. Here, we detail these recent achievements and ask whether simulations have indeed rendered quantitative predictions in several areas, including protein folding kinetics, thermodynamics, and physics-based methods for structure prediction. We conclude by looking to the future of such comparisons between simulations and experiments. | - |
dc.language | English | - |
dc.publisher | ANNUAL REVIEWS | - |
dc.subject | MOLECULAR-DYNAMICS SIMULATIONS | - |
dc.subject | FREE-ENERGY LANDSCAPE | - |
dc.subject | ANTIPARALLEL BETA-SHEET | - |
dc.subject | REPLICA-EXCHANGE METHOD | - |
dc.subject | IMPLICIT SOLVENT MODEL | - |
dc.subject | SINGLE-DOMAIN PROTEINS | - |
dc.subject | PHI-VALUE ANALYSIS | - |
dc.subject | TRANSITION-STATE | - |
dc.subject | CHYMOTRYPSIN INHIBITOR-2 | - |
dc.subject | EXPLICIT SOLVENT | - |
dc.title | How well can simulation predict protein folding kinetics and thermodynamics? | - |
dc.type | Article | - |
dc.identifier.wosid | 000230099600003 | - |
dc.identifier.scopusid | 2-s2.0-20544464457 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.beginningpage | 43 | - |
dc.citation.endingpage | 69 | - |
dc.citation.publicationname | ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | - |
dc.identifier.doi | 10.1146/annurev.biophys.34.040204.144447 | - |
dc.contributor.localauthor | Rhee, Young Min | - |
dc.contributor.nonIdAuthor | Snow, CD | - |
dc.contributor.nonIdAuthor | Sorin, EJ | - |
dc.contributor.nonIdAuthor | Pande, VS | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review; Book Chapter | - |
dc.subject.keywordAuthor | folding rate | - |
dc.subject.keywordAuthor | molecular dynamics | - |
dc.subject.keywordAuthor | transition state ensemble | - |
dc.subject.keywordAuthor | P(fold) reaction coordinate | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS SIMULATIONS | - |
dc.subject.keywordPlus | FREE-ENERGY LANDSCAPE | - |
dc.subject.keywordPlus | ANTIPARALLEL BETA-SHEET | - |
dc.subject.keywordPlus | REPLICA-EXCHANGE METHOD | - |
dc.subject.keywordPlus | IMPLICIT SOLVENT MODEL | - |
dc.subject.keywordPlus | SINGLE-DOMAIN PROTEINS | - |
dc.subject.keywordPlus | PHI-VALUE ANALYSIS | - |
dc.subject.keywordPlus | TRANSITION-STATE | - |
dc.subject.keywordPlus | CHYMOTRYPSIN INHIBITOR-2 | - |
dc.subject.keywordPlus | EXPLICIT SOLVENT | - |
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