DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, KW | ko |
dc.contributor.author | Choi, B | ko |
dc.contributor.author | Kim, YM | ko |
dc.contributor.author | Cho, CW | ko |
dc.contributor.author | Park, H | ko |
dc.contributor.author | Moon, JI | ko |
dc.contributor.author | Choi, GS | ko |
dc.contributor.author | Park, JB | ko |
dc.contributor.author | Kim, SJ | ko |
dc.date.accessioned | 2017-07-18T05:42:58Z | - |
dc.date.available | 2017-07-18T05:42:58Z | - |
dc.date.created | 2017-07-03 | - |
dc.date.created | 2017-07-03 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | TRANSPLANTATION PROCEEDINGS, v.49, no.5, pp.1153 - 1159 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | http://hdl.handle.net/10203/224786 | - |
dc.description.abstract | Background. Although the induction of mixed allogeneic chimera shows promising clinical tolerance results in organ transplantation, its clinical relevance as an anti-cancer therapy is yet unknown. We introduced a mixed allogenic chimera setting with the use of a murine colon cancer cell line, CT26, by performing double bone marrow transplantation. Methods. We analyzed donor- and recipient-restricted anti-cancer T-cell responses, and phenotypes of subpopulations of T cells. The protocol involves challenging 1 x 10(5) cells of CT26 cells intra-hepatically on day 50 after bone marrow transplantation, and, by use of CT26 lysates and an H-2L(d)-restricted AH1 pentamer, flow cytometric analysis was performed to detect the generation of cancer-specific CD4(+) and CD8(+) T cells at various time points. Results. We found that immunocompetence against tumors depends heavily on cancer specific CD8(+) T-cell responses in a major histocompatibility complex-restricted manner; the evidence was further supported by the increase of interferon-gamma-secreting CD4(+) T cells. Moreover, we demonstrated that during the effector immune response to CT26 cancer challenge, there was a presence of central memory cells (CD62L(hi)CCR7(+)) as well as effector memory cells (CD62L(lo)CCR7(-)). Moreover, mixed allogeneic chimeras (BALB/c to C56BL/6 or vice versa) showed similar or heightened immune responses to CT26 cells compared with that of wild-type mice. Conclusions. Our results suggest that the responses of primary immunocompetency and of pre-existing memory T cells against allogeneic cancer are sustained and preserved long-term in a mixed allogeneic chimeric environment. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | BONE-MARROW-TRANSPLANTATION | - |
dc.subject | TOLERANCE INDUCTION | - |
dc.subject | MEDIATED ALLORESISTANCE | - |
dc.subject | 2-SIGNAL BLOCKADE | - |
dc.subject | HOST-DISEASE | - |
dc.subject | RECIPIENTS | - |
dc.subject | SURVIVAL | - |
dc.subject | ANTIBODY | - |
dc.subject | DELETION | - |
dc.subject | GRAFTS | - |
dc.title | Major Histocompatibilty Complex-Restricted Adaptive Immune Responses to CT26 Colon Cancer Cell Line in Mixed Allogeneic Chimera | - |
dc.type | Article | - |
dc.identifier.wosid | 000403382400050 | - |
dc.identifier.scopusid | 2-s2.0-85020071499 | - |
dc.type.rims | ART | - |
dc.citation.volume | 49 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 1153 | - |
dc.citation.endingpage | 1159 | - |
dc.citation.publicationname | TRANSPLANTATION PROCEEDINGS | - |
dc.identifier.doi | 10.1016/j.transproceed.2017.03.011 | - |
dc.contributor.localauthor | Kim, YM | - |
dc.contributor.nonIdAuthor | Lee, KW | - |
dc.contributor.nonIdAuthor | Choi, B | - |
dc.contributor.nonIdAuthor | Cho, CW | - |
dc.contributor.nonIdAuthor | Park, H | - |
dc.contributor.nonIdAuthor | Moon, JI | - |
dc.contributor.nonIdAuthor | Choi, GS | - |
dc.contributor.nonIdAuthor | Park, JB | - |
dc.contributor.nonIdAuthor | Kim, SJ | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | TOLERANCE INDUCTION | - |
dc.subject.keywordPlus | MEDIATED ALLORESISTANCE | - |
dc.subject.keywordPlus | 2-SIGNAL BLOCKADE | - |
dc.subject.keywordPlus | HOST-DISEASE | - |
dc.subject.keywordPlus | RECIPIENTS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | DELETION | - |
dc.subject.keywordPlus | GRAFTS | - |
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