DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jinyong | ko |
dc.contributor.author | Lee, Dong Yun | ko |
dc.contributor.author | Kang, Sukmo | ko |
dc.contributor.author | Miao, Wenjun | ko |
dc.contributor.author | Kim, Hyungjun | ko |
dc.contributor.author | Lee, Yonghyun | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2017-06-16T03:57:15Z | - |
dc.date.available | 2017-06-16T03:57:15Z | - |
dc.date.created | 2017-06-05 | - |
dc.date.created | 2017-06-05 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | BIOMATERIALS, v.133, pp.1 - 10 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/224039 | - |
dc.description.abstract | Hepatic ischemia-reperfusion injury (IRI) remains a major concern in liver transplantation and resection, despite continuing efforts to prevent it. Accumulating evidence suggests that bilirubin possesses antioxidant, anti-inflammatory and anti-apoptotic properties. However, despite obvious potential health benefits of bilirubin, its clinical applications are limited by its poor solubility. We recently developed bilirubin nanoparticles (BRNPs) consisting of polyethylene glycol (PEG)-conjugated bilirubin. Here, we sought to investigate whether BRNPs protect against IRI in the liver by preventing oxidative stress. BRNPs exerted potent antioxidant and anti-apoptotic activity in primary hepatocytes exposed to hydrogen peroxide, a precursor of reactive oxygen species (ROS). In a model of hepatic IRI in mice, BRNP preconditioning exerted profound protective effects against hepatocellular injury by reducing oxidative stress, pro-inflammatory cytokine production, and recruitment of neutrophils. They also preferentially accumulated in IRI-induced inflammatory lesions. Collectively, our findings indicate that BRNP preconditioning provides a simple and safe approach that can be easily monitored in the blood like endogenous bilirubin, and could be a promising strategy to protect against IRI in a clinical setting. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | LIVER-TRANSPLANTATION | - |
dc.subject | REACTIVE OXYGEN | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | STRATEGIES | - |
dc.subject | THERAPY | - |
dc.subject | DISEASE | - |
dc.title | Bilirubin nanoparticle preconditioning protects against hepatic ischemia-reperfusion injury | - |
dc.type | Article | - |
dc.identifier.wosid | 000401716700001 | - |
dc.identifier.scopusid | 2-s2.0-85017452758 | - |
dc.type.rims | ART | - |
dc.citation.volume | 133 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 10 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.04.011 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Miao, Wenjun | - |
dc.contributor.nonIdAuthor | Kim, Hyungjun | - |
dc.contributor.nonIdAuthor | Lee, Yonghyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bilirubin | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Ischemia-reperfusion injury | - |
dc.subject.keywordAuthor | Liver transplantation | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Anti-inflammatory therapy | - |
dc.subject.keywordPlus | LIVER-TRANSPLANTATION | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DISEASE | - |
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