DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jiye | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.date.accessioned | 2017-05-10T04:15:23Z | - |
dc.date.available | 2017-05-10T04:15:23Z | - |
dc.date.created | 2017-03-16 | - |
dc.date.created | 2017-03-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.7 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/223593 | - |
dc.description.abstract | Emotional contagion, a primitive form of empathy, is heightened in patients with Alzheimer's disease (AD); however, the mechanism underlying this attribute has not been thoroughly elucidated. In this study, observational fear conditioning was performed to measure emotional contagion levels in a mouse model of AD. Simultaneous recording of local field potentials in the bilateral anterior insula, basolateral amygdala, anterior cingulate cortex, and retrosplenial cortex was also conducted to investigate related brain network changes. Consistent with the results obtained with AD patients, 11-month-old AD model mice exhibited significantly higher freezing levels in observational fear conditioning, indicating elevated emotional contagion compared to age-matched wild-type mice. Furthermore, the left anterior insula and right basolateral amygdala of 11-months-old AD model mice indicated sustained increases in synchronization when they observed the suffering of conspecifics. These changes did not appear in other age groups or wild-type controls. Additionally, the amyloid plaque burden within the anterior insula was significantly correlated with the freezing levels in observational fear conditioning. Taken together, this study reveals increased and sustained network synchrony between the anterior insula and basolateral amygdala, which comprise a salience network in humans, as a potential mechanism for elevated emotional contagion in a mouse model of AD. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NON-COGNITIVE BEHAVIORS | - |
dc.subject | NEUROPSYCHIATRIC SYMPTOMS | - |
dc.subject | FRONTOTEMPORAL DEMENTIA | - |
dc.subject | NETWORK | - |
dc.subject | CONNECTIVITY | - |
dc.subject | DEPRESSION | - |
dc.subject | CORTEX | - |
dc.subject | BRAIN | - |
dc.subject | MICE | - |
dc.subject | LATERALIZATION | - |
dc.title | Elevated emotional contagion in a mouse model of Alzheimer's disease is associated with increased synchronization in the insula and amygdala | - |
dc.type | Article | - |
dc.identifier.wosid | 000398640300001 | - |
dc.identifier.scopusid | 2-s2.0-85017208396 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep46262 | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NON-COGNITIVE BEHAVIORS | - |
dc.subject.keywordPlus | NEUROPSYCHIATRIC SYMPTOMS | - |
dc.subject.keywordPlus | FRONTOTEMPORAL DEMENTIA | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | CONNECTIVITY | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | LATERALIZATION | - |
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