DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Junsu | ko |
dc.contributor.author | Choi, Jaesung | ko |
dc.contributor.author | Chung, Seokang | ko |
dc.contributor.author | Park, JooYong | ko |
dc.contributor.author | Kim, Ji-Eun | ko |
dc.contributor.author | Sung, Hyuna | ko |
dc.contributor.author | Han, Wonshik | ko |
dc.contributor.author | Lee, Jong Won | ko |
dc.contributor.author | Park, Sue K. | ko |
dc.contributor.author | Kim, Mi Kyung | ko |
dc.contributor.author | Ahn, Sei-Hyun | ko |
dc.contributor.author | Noh, Dong-Young | ko |
dc.contributor.author | Yoo, Keun-Young | ko |
dc.contributor.author | Kang, Daehee | ko |
dc.contributor.author | Choi, Ji-Yeob | ko |
dc.date.accessioned | 2017-05-08T08:45:28Z | - |
dc.date.available | 2017-05-08T08:45:28Z | - |
dc.date.created | 2017-04-18 | - |
dc.date.created | 2017-04-18 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | JOURNAL OF BREAST CANCER, v.20, no.1, pp.27 - 34 | - |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.uri | http://hdl.handle.net/10203/223441 | - |
dc.description.abstract | Purpose: The high mobility group box 1 (HMGB1) protein has roles in apoptosis and immune responses by acting as a ligand for receptor for advanced glycation end products (RAGE), Toll like receptors (TLRs), and triggering receptor expressed on myeloid cells 1. In particular, HMGB1/RAGE is involved in tumor metastasis by inducing matrix metalloproteinase 2 (MMP2) and MMP9 expression. We investigated the associations between genetic variations in HMGB1-related genes and disease -free survival (DFS) and overall survival (OS) in Korean female breast cancer patients. Methods: A total of 2,027 patients in the Seoul Breast Cancer Study were included in the analysis. One hundred sixteen single nucleotide polymorphisms (SNPs) were extracted from eight genes. A multivariate Cox proportional hazards model was used to estimate the hazard ratio and 95% confidence interval (CI) of each SNP. The effects of the SNPs on breast cancer prognosis were assessed at cumulative levels with polygenic risk scores. Results: The SNPs significantly associated with DFS were rs243867 (hazard ratio, 1.26; 95% CI, 1.05-1.50) and rs243842 (hazard ratio, 1.24; 95% CI, 1.03-1.50); both SNPs were in MMP2. The SNPs significantly associated with OS were rs243842 in MMP2 (hazard ratio, 1.33; 95% CI 1.03-1.71), rs4145277 in HMGB1 (hazard ratio, 1.29; 95% CI, 1.00-1.66), rs7656411 in TLR2 (hazard ratio, 0.76; 95% CI, 0.60-0.98), and rs7045953 in TLR4 (hazard ratio, 0.50; 95% CI, 0.29-0.84). The polygenic risk score results for the DFS and OS patients showed third tertile hazard ratios of 1.72 (95% CI, 1.27-2.34) and 2.75 (95% CI, 1.79-4.23), respectively, over their first tertile references. Conclusion: The results of the present study indicate that genetic polymorphisms in HMGB1-related genes are related to breast cancer prognosis in Korean women. | - |
dc.language | English | - |
dc.publisher | KOREAN BREAST CANCER SOC | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | RECEPTOR | - |
dc.subject | HMGB1 | - |
dc.subject | ASSOCIATION | - |
dc.subject | PATHWAY | - |
dc.subject | CELLS | - |
dc.subject | RISK | - |
dc.subject | INFLAMMATION | - |
dc.subject | PROGRESSION | - |
dc.subject | STATISTICS | - |
dc.title | Genetic Predisposition of Polymorphisms in HMGB1-Related Genes to Breast Cancer Prognosis in Korean Women | - |
dc.type | Article | - |
dc.identifier.wosid | 000397832500004 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 27 | - |
dc.citation.endingpage | 34 | - |
dc.citation.publicationname | JOURNAL OF BREAST CANCER | - |
dc.identifier.doi | 10.4048/jbc.2017.20.1.27 | - |
dc.contributor.localauthor | Lee, Junsu | - |
dc.contributor.nonIdAuthor | Choi, Jaesung | - |
dc.contributor.nonIdAuthor | Chung, Seokang | - |
dc.contributor.nonIdAuthor | Park, JooYong | - |
dc.contributor.nonIdAuthor | Kim, Ji-Eun | - |
dc.contributor.nonIdAuthor | Sung, Hyuna | - |
dc.contributor.nonIdAuthor | Han, Wonshik | - |
dc.contributor.nonIdAuthor | Lee, Jong Won | - |
dc.contributor.nonIdAuthor | Park, Sue K. | - |
dc.contributor.nonIdAuthor | Kim, Mi Kyung | - |
dc.contributor.nonIdAuthor | Ahn, Sei-Hyun | - |
dc.contributor.nonIdAuthor | Noh, Dong-Young | - |
dc.contributor.nonIdAuthor | Yoo, Keun-Young | - |
dc.contributor.nonIdAuthor | Kang, Daehee | - |
dc.contributor.nonIdAuthor | Choi, Ji-Yeob | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | HMGB1 protein | - |
dc.subject.keywordAuthor | Matrix metalloproteinase 2 | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | HMGB1 | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | STATISTICS | - |
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