Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic Species

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dc.contributor.authorLee, Chang-Hanko
dc.contributor.authorPark, Chankyuko
dc.date.accessioned2017-04-17T07:41:24Z-
dc.date.available2017-04-17T07:41:24Z-
dc.date.created2017-04-10-
dc.date.created2017-04-10-
dc.date.issued2017-01-
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.18, no.1-
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10203/223331-
dc.description.abstractGlyoxal (GO) and methylglyoxal (MG), belonging to alpha-oxoaldehydes, are produced by organisms from bacteria to humans by glucose oxidation, lipid peroxidation, and DNA oxidation. Since glyoxals contain two adjacent reactive carbonyl groups, they are referred to as reactive electrophilic species (RES), and are damaging to proteins and nucleotides. Therefore, glyoxals cause various diseases in humans, such as diabetes and neurodegenerative diseases, from which all living organisms need to be protected. Although the glyoxalase system has been known for some time, details on how glyoxals are sensed and detoxified in the cell have not been fully elucidated, and are only beginning to be uncovered. In this review, we will summarize the current knowledge on bacterial responses to glyoxal, and specifically focus on the glyoxal-associated regulators YqhC and NemR, as well as their detoxification mediated by glutathione (GSH)-dependent/independent glyoxalases and NAD(P)H-dependent reductases. Furthermore, we will address questions and future directions.-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.subjectESCHERICHIA-COLI K-12-
dc.subjectGLYCATION END-PRODUCTS-
dc.subjectN-ETHYLMALEIMIDE REDUCTASE-
dc.subjectALDO-KETO REDUCTASES-
dc.subjectTRANSCRIPTION FACTOR-
dc.subjectALDEHYDE REDUCTASE-
dc.subjectMETABOLIC PATHWAY-
dc.subjectOXIDATIVE STRESS-
dc.subjectCROSS-LINKING-
dc.subjectEFFLUX SYSTEM-
dc.titleBacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic Species-
dc.typeArticle-
dc.identifier.wosid000393030600167-
dc.identifier.scopusid2-s2.0-85009861490-
dc.type.rimsART-
dc.citation.volume18-
dc.citation.issue1-
dc.citation.publicationnameINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.identifier.doi10.3390/ijms18010169-
dc.contributor.localauthorPark, Chankyu-
dc.description.isOpenAccessY-
dc.type.journalArticleReview-
dc.subject.keywordAuthorglyoxal-
dc.subject.keywordAuthorreactive electrophilic species (RES)-
dc.subject.keywordAuthorglyoxalase-
dc.subject.keywordPlusESCHERICHIA-COLI K-12-
dc.subject.keywordPlusGLYCATION END-PRODUCTS-
dc.subject.keywordPlusN-ETHYLMALEIMIDE REDUCTASE-
dc.subject.keywordPlusALDO-KETO REDUCTASES-
dc.subject.keywordPlusTRANSCRIPTION FACTOR-
dc.subject.keywordPlusALDEHYDE REDUCTASE-
dc.subject.keywordPlusMETABOLIC PATHWAY-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusCROSS-LINKING-
dc.subject.keywordPlusEFFLUX SYSTEM-
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