DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Sehee | ko |
dc.contributor.author | Jeong, Dongjin | ko |
dc.contributor.author | Oh, Sae Jin | ko |
dc.contributor.author | Ahn, Jiye | ko |
dc.contributor.author | Lee, Seung Hyo | ko |
dc.contributor.author | Chung, Doo Hyun | ko |
dc.date.accessioned | 2017-04-17T07:28:47Z | - |
dc.date.available | 2017-04-17T07:28:47Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | IMMUNOLOGY LETTERS, v.182, pp.50 - 56 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | http://hdl.handle.net/10203/223276 | - |
dc.description.abstract | Natural Killer T(NKT) cells are distinct T cell subset that link innate and adaptive immune responses. IL-1 beta , produced by various immune cells, plays a key role in the regulation of innate immunity in vivo. However, it is unclear whether NKT cells regulate IL-1 beta production by macrophages. To address this, we co-cultured NKT cells and peritoneal macrophages in the presence of TCR stimulation and inflammasome activators. Among cytokines secreted from NKT cells, GM-CSF enhanced IL-1 beta production by macrophages via regulating LPS-mediated pro-IL-1 beta expression and NLRP3-dependent inflammasome activation, whereas IL-4 enhanced M2-differentiation of macrophages and decreased IL-1 beta production. Together, our findings suggest the NKT cells have double-sided effects on IL-1 beta-mediated innate immune responses by producing IL-4 and GM-CSF. These findings may be helpful for a comprehensive understanding of NKT cell-mediated regulatory mechanisms of the pro-inflammatory effects of IL-1 beta in inflammatory diseases in vivo. (C)2017 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | ACTIVATION | - |
dc.subject | CYTOKINE | - |
dc.subject | SUBSETS | - |
dc.subject | BIOLOGY | - |
dc.subject | BETA | - |
dc.title | GM-CSF and IL-4 produced by NKT cells inversely regulate IL-1 beta production by macrophages | - |
dc.type | Article | - |
dc.identifier.wosid | 000395214600007 | - |
dc.identifier.scopusid | 2-s2.0-85009956061 | - |
dc.type.rims | ART | - |
dc.citation.volume | 182 | - |
dc.citation.beginningpage | 50 | - |
dc.citation.endingpage | 56 | - |
dc.citation.publicationname | IMMUNOLOGY LETTERS | - |
dc.identifier.doi | 10.1016/j.imlet.2017.01.003 | - |
dc.contributor.localauthor | Lee, Seung Hyo | - |
dc.contributor.nonIdAuthor | Ahn, Sehee | - |
dc.contributor.nonIdAuthor | Jeong, Dongjin | - |
dc.contributor.nonIdAuthor | Oh, Sae Jin | - |
dc.contributor.nonIdAuthor | Ahn, Jiye | - |
dc.contributor.nonIdAuthor | Chung, Doo Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | NKT cells | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | IL-lb | - |
dc.subject.keywordAuthor | GM-CSF | - |
dc.subject.keywordAuthor | IL-4 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | BETA | - |
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