Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's beta-Amyloid Aggregation

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dc.contributor.authorKuk, Su Keunko
dc.contributor.authorLee, Byung Ilko
dc.contributor.authorLee, Joon Seokko
dc.contributor.authorPark, Chan Beumko
dc.date.accessioned2017-04-17T07:27:34Z-
dc.date.available2017-04-17T07:27:34Z-
dc.date.created2017-04-10-
dc.date.created2017-04-10-
dc.date.created2017-04-10-
dc.date.issued2017-03-
dc.identifier.citationSMALL, v.13, no.11-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10203/223251-
dc.description.abstractRose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aβ aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4:Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self-assembly under NIR irradiation by generating 1O2. Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ-induced cytotoxicity.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleRattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's beta-Amyloid Aggregation-
dc.typeArticle-
dc.identifier.wosid000397703600003-
dc.identifier.scopusid2-s2.0-85015329583-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue11-
dc.citation.publicationnameSMALL-
dc.identifier.doi10.1002/smll.201603139-
dc.contributor.localauthorPark, Chan Beum-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusPHOTODYNAMIC THERAPY-
dc.subject.keywordPlusPEPTIDE AGGREGATION-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusPHOTOSENSITIZERS-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusFIBRILLATION-
dc.subject.keywordPlusTOXICITY-
dc.subject.keywordPlusPROTEINS-
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