DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yeha | ko |
dc.contributor.author | Lim, Soyeon | ko |
dc.contributor.author | Ha, Tae Jeong | ko |
dc.contributor.author | Song, You Hyang | ko |
dc.contributor.author | Sohn, Young In | ko |
dc.contributor.author | Park, Dae-Jin | ko |
dc.contributor.author | Paik, Sun-Sook | ko |
dc.contributor.author | Kim-Kaneyama, Joo-ri | ko |
dc.contributor.author | Song, Mi-Ryoung | ko |
dc.contributor.author | Leung, Amanda | ko |
dc.contributor.author | Levine, Edward M. | ko |
dc.contributor.author | Kim, In-Beom | ko |
dc.contributor.author | Goo, Yong-Sook | ko |
dc.contributor.author | Lee, Seung-Hee | ko |
dc.contributor.author | Kang, Kyung-Hwa | ko |
dc.contributor.author | Kim, Jin Woo | ko |
dc.date.accessioned | 2017-03-31T05:40:52Z | - |
dc.date.available | 2017-03-31T05:40:52Z | - |
dc.date.created | 2017-02-19 | - |
dc.date.created | 2017-02-19 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | ELIFE, v.6 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10203/222775 | - |
dc.description.abstract | The visual responses of vertebrates are sensitive to the overall composition of retinal interneurons including amacrine cells, which tune the activity of the retinal circuitry. The expression of Paired-homeobox 6 (PAX6) is regulated by multiple cis-DNA elements including the intronic alpha-enhancer, which is active in GABAergic amacrine cell subsets. Here, we report that the transforming growth factor beta 1-induced transcript 1 protein (Tgfb1i1) interacts with the LIM domain transcription factors Lhx3 and Isl1 to inhibit the a-enhancer in the post-natal mouse retina. Tgfb1i1(-/-) mice show elevated a-enhancer activity leading to overproduction of Pax6 Delta PD isoform that supports the GABAergic amacrine cell fate maintenance. Consequently, the Tgfb1i1(-/-) mouse retinas show a sustained light response, which becomes more transient in mice with the auto-stimulation-defective Pax6(Delta PBS/Delta PBS) mutation. Together, we show the antagonistic regulation of the a-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation. | - |
dc.language | English | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.subject | HOMEODOMAIN TRANSCRIPTION FACTOR | - |
dc.subject | ROD BIPOLAR CELLS | - |
dc.subject | PAIRED DOMAIN | - |
dc.subject | PROGENITOR CELLS | - |
dc.subject | BINDING-PROTEIN | - |
dc.subject | DNA RECOGNITION | - |
dc.subject | RAT RETINA | - |
dc.subject | GENE | - |
dc.subject | EXPRESSION | - |
dc.subject | SPECIFICATION | - |
dc.title | The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity | - |
dc.type | Article | - |
dc.identifier.wosid | 000394260200001 | - |
dc.identifier.scopusid | 2-s2.0-85013414298 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.publicationname | ELIFE | - |
dc.identifier.doi | 10.7554/eLife.21303 | - |
dc.contributor.localauthor | Lee, Seung-Hee | - |
dc.contributor.localauthor | Kim, Jin Woo | - |
dc.contributor.nonIdAuthor | Park, Dae-Jin | - |
dc.contributor.nonIdAuthor | Paik, Sun-Sook | - |
dc.contributor.nonIdAuthor | Kim-Kaneyama, Joo-ri | - |
dc.contributor.nonIdAuthor | Song, Mi-Ryoung | - |
dc.contributor.nonIdAuthor | Leung, Amanda | - |
dc.contributor.nonIdAuthor | Levine, Edward M. | - |
dc.contributor.nonIdAuthor | Kim, In-Beom | - |
dc.contributor.nonIdAuthor | Goo, Yong-Sook | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HOMEODOMAIN TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | ROD BIPOLAR CELLS | - |
dc.subject.keywordPlus | PAIRED DOMAIN | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | DNA RECOGNITION | - |
dc.subject.keywordPlus | RAT RETINA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SPECIFICATION | - |
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